Documentos: 
1. (�)
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy
- Sarma, Satyam; Li, Na; van Oort, Ralph J.; Reynolds, Corey; Skapura, Darlene G.; Wehrens, Xander H. T.
Aberrant intracellular Ca2+ regulation is believed to contribute to the development of ... phosphorylation of RyR2 at S2808 contributes to abnormal Ca2+ homeostasis associated with dystrophic - 30-jul-2011
2. (�)
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification
- Wang, Jun; Klysik, Elzbieta; Sood, Subeena; Johnson, Randy L.; Wehrens, Xander H. T.; Martin, James F.
association studies implicated a region of human chromosome 4q25 in familial AF and AFL, ≈150 kb distal to the Pitx2 homeobox gene, a developmental left–right asymmetry (LRA) gene. To investigate the - 30-jul-2011
3. (�)
Stress synchronizes calcium release and promotes SR calcium leak
- Wang, Wei; Wehrens, Xander H T
- 30-jul-2011
4. (�)
Animal models of arrhythmogenic cardiomyopathy
- McCauley, Mark D.; Wehrens, Xander H. T.
Arrhythmogenic cardiomyopathies are a heterogeneous group of pathological conditions that give rise to myocardial dysfunction with an increased risk for atrial or ventricular arrhythmias. Inherited - 28-jul-2011
5. (�)
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation
- Shao, Chun-Hong; Wehrens, Xander H. T.; Wyatt, Todd A.; Parbhu, Sheeva; Rozanski, George J.; Patel, Kaushik P.; Bidasee, Keshore R.
The present study was undertaken to assess the effects of exercise training (ExT) initiated after ... response to Ca2+ was altered. RyR2 also exhibited 1.8- and 1.5-fold increases in phosphorylation at - 28-jul-2011
6. (�)
Molecular evolution of the junctophilin gene family
- Garbino, Alejandro; van Oort, Ralph J.; Dixit, Sayali S.; Landstrom, Andrew P.; Ackerman, Michael J.; Wehrens, Xander H. T.
channels and intracellular calcium release channels. To determine the molecular evolution of the JPH - 28-jul-2011
7. (�)
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
- Wu, Yuejin; Gao, Zhan; Chen, Biyi; Koval, Olha M.; Singh, Madhu V.; Guan, Xiaoqun; Hund, Thomas J.; Kutschke, William; Sarma, Satyam; Grumbach, Isabella M.; Wehrens, Xander H. T.; Mohler, Peter J.; Song, Long-Sheng; Anderson, Mark E.
membrane diastolic depolarization rate (DDR), leading to faster SAN action potential generation. Surprisingly, HCN4 knockout mice were recently shown to retain physiological HR increases with - 08-oct-2009
8. (�)
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy
- Kannankeril, Prince J.; Mitchell, Brett M.; Goonasekera, Sanjeewa A.; Chelu, Mihail G.; Zhang, Wei; Sood, Subeena; Kearney, Debra L.; Danila, Cristina I.; De Biasi, Mariella; Wehrens, Xander H. T.; Pautler, Robia G.; Roden, Dan M.; Taffet, George E.; Dirksen, Robert T.; Anderson, Mark E.; Hamilton, Susan L.
polymorphic ventricular tachycardia and a form of arrhythmogenic right ventricular dysplasia. To study ... RyR2R176Q/+ mice compared with controls, indicating subtle functional impairment due to the presence of - 12-mar-2008
9. (�)
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias
- Lehnart, Stephan E.; Terrenoire, Cecile; Reiken, Steven; Wehrens, Xander H. T.; Song, Long-Sheng; Tillman, Erik J.; Mancarella, Salvatore; Coromilas, James; Lederer, W. J.; Kass, Robert S.; Marks, Andrew R.
Catecholaminergic polymorphic ventricular tachycardia is a form of exercise-induced sudden cardiac death that has been linked to mutations in the cardiac Ca2+ release channel/ryanodine receptor (RyR2 - 11-mar-2008
10. (�)
Analysis of calstabin2 (FKBP12.6)ryanodine receptor interactions: Rescue of heart failure by calstabin2 in mice
- Huang, Fannie; Shan, Jian; Reiken, Steven; Wehrens, Xander H. T.; Marks, Andrew R.
residue (Asp-37) has been neutralized binds to a mutant RyR2 channel that mimics constitutively PKA ... calstabin2 that are involved in binding to RyR2 and likely play a role in PKA phosphorylation-induced - 10-mar-2008 | |
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