Documentos: 
1. (�)
Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides
- Ho, Hsiang-Ting; Liu, Bin; Snyder, Jedidiah S.; Lou, Qing; Brundage, Elizabeth A.; Velez-Cortes, Florencia; Wang, Honglan; Ziolo, Mark T.; Anderson, Mark E.; Sen, Chandan K.; Wehrens, Xander H.T.; Fedorov, Vadim V.; Biesiadecki, Brandon J.; Hund, Thomas J.; Györke, Sándor
- 02-ene-2015
2. (�)
Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation
- Wang, Jun; Bai, Yan; Li, Na; Ye, Wenduo; Zhang, Min; Greene, Stephanie B.; Tao, Ye; Chen, Yiping; Wehrens, Xander H. T.; Martin, James F.
. It is critical to elucidate the molecular mechanisms underlying AF, given that the prevalence of AF is expected to dramatically increase as the human population ages. We identified a microRNA (miR - 25-dic-2014
3. (�)
Calcium dysregulation in atrial fibrillation: the role of CaMKII
- Heijman, Jordi; Voigt, Niels; Wehrens, Xander H. T.; Dobrev, Dobromir
make it more difficult to treat. Recent research has suggested an important role for Ca2+-dysregulation ... arrhythmogenic mechanisms contributing to the initiation and maintenance of AF. In addition, AF is self - 14-mar-2014
4. (�)
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy
- Sarma, Satyam; Li, Na; van Oort, Ralph J.; Reynolds, Corey; Skapura, Darlene G.; Wehrens, Xander H. T.
Aberrant intracellular Ca2+ regulation is believed to contribute to the development of ... phosphorylation of RyR2 at S2808 contributes to abnormal Ca2+ homeostasis associated with dystrophic - 30-jul-2011
5. (�)
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification
- Wang, Jun; Klysik, Elzbieta; Sood, Subeena; Johnson, Randy L.; Wehrens, Xander H. T.; Martin, James F.
association studies implicated a region of human chromosome 4q25 in familial AF and AFL, ≈150 kb distal to the Pitx2 homeobox gene, a developmental left–right asymmetry (LRA) gene. To investigate the - 30-jul-2011
6. (�)
Stress synchronizes calcium release and promotes SR calcium leak
- Wang, Wei; Wehrens, Xander H T
- 30-jul-2011
7. (�)
Animal models of arrhythmogenic cardiomyopathy
- McCauley, Mark D.; Wehrens, Xander H. T.
Arrhythmogenic cardiomyopathies are a heterogeneous group of pathological conditions that give rise to myocardial dysfunction with an increased risk for atrial or ventricular arrhythmias. Inherited - 28-jul-2011
8. (�)
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation
- Shao, Chun-Hong; Wehrens, Xander H. T.; Wyatt, Todd A.; Parbhu, Sheeva; Rozanski, George J.; Patel, Kaushik P.; Bidasee, Keshore R.
The present study was undertaken to assess the effects of exercise training (ExT) initiated after ... response to Ca2+ was altered. RyR2 also exhibited 1.8- and 1.5-fold increases in phosphorylation at - 28-jul-2011
9. (�)
Molecular evolution of the junctophilin gene family
- Garbino, Alejandro; van Oort, Ralph J.; Dixit, Sayali S.; Landstrom, Andrew P.; Ackerman, Michael J.; Wehrens, Xander H. T.
channels and intracellular calcium release channels. To determine the molecular evolution of the JPH - 28-jul-2011
10. (�)
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
- Wu, Yuejin; Gao, Zhan; Chen, Biyi; Koval, Olha M.; Singh, Madhu V.; Guan, Xiaoqun; Hund, Thomas J.; Kutschke, William; Sarma, Satyam; Grumbach, Isabella M.; Wehrens, Xander H. T.; Mohler, Peter J.; Song, Long-Sheng; Anderson, Mark E.
membrane diastolic depolarization rate (DDR), leading to faster SAN action potential generation. Surprisingly, HCN4 knockout mice were recently shown to retain physiological HR increases with - 08-oct-2009 | |
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