4. (�)Animal models of arrhythmogenic cardiomyopathy - McCauley, Mark D.; Wehrens, XanderH. T.
Arrhythmogenic cardiomyopathies are a heterogeneous group of pathological conditions that give rise to myocardial dysfunction with an increased risk for atrial or ventricular arrhythmias. Inherited
5. (�)Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation - Shao, Chun-Hong; Wehrens, XanderH. T.; Wyatt, Todd A.; Parbhu, Sheeva; Rozanski, George J.; Patel, Kaushik P.; Bidasee, Keshore R.
The present study was undertaken to assess the effects of exercise training (ExT) initiated after ... response to Ca2+ was altered. RyR2 also exhibited 1.8- and 1.5-fold increases in phosphorylation at
6. (�)Molecular evolution of the junctophilin gene family - Garbino, Alejandro; van Oort, Ralph J.; Dixit, Sayali S.; Landstrom, Andrew P.; Ackerman, Michael J.; Wehrens, XanderH. T.
channels and intracellular calcium release channels. To determine the molecular evolution of the JPH
7. (�)Calmodulin kinase II is required for fight or flight sinoatrial node physiology - Wu, Yuejin; Gao, Zhan; Chen, Biyi; Koval, Olha M.; Singh, Madhu V.; Guan, Xiaoqun; Hund, Thomas J.; Kutschke, William; Sarma, Satyam; Grumbach, Isabella M.; Wehrens, XanderH. T.; Mohler, Peter J.; Song, Long-Sheng; Anderson, Mark E.
membrane diastolic depolarization rate (DDR), leading to faster SAN action potential generation. Surprisingly, HCN4 knockout mice were recently shown to retain physiological HR increases with
8. (�)Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy - Kannankeril, Prince J.; Mitchell, Brett M.; Goonasekera, Sanjeewa A.; Chelu, Mihail G.; Zhang, Wei; Sood, Subeena; Kearney, Debra L.; Danila, Cristina I.; De Biasi, Mariella; Wehrens, XanderH. T.; Pautler, Robia G.; Roden, Dan M.; Taffet, George E.; Dirksen, Robert T.; Anderson, Mark E.; Hamilton, Susan L.
polymorphic ventricular tachycardia and a form of arrhythmogenic right ventricular dysplasia. To study ... RyR2R176Q/+ mice compared with controls, indicating subtle functional impairment due to the presence of
9. (�)Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias - Lehnart, Stephan E.; Terrenoire, Cecile; Reiken, Steven; Wehrens, XanderH. T.; Song, Long-Sheng; Tillman, Erik J.; Mancarella, Salvatore; Coromilas, James; Lederer, W. J.; Kass, Robert S.; Marks, Andrew R.
Catecholaminergic polymorphic ventricular tachycardia is a form of exercise-induced sudden cardiac death that has been linked to mutations in the cardiac Ca2+ release channel/ryanodine receptor (RyR2