Control of Filament Formation in Candida albicans by Polyamine Levels
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Control of Filament Formation in Candida albicans by Polyamine Levels
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| Id. |
17652785 |
| Idioma |
inglés
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| Titulo |
Control of Filament Formation in Candida albicans by Polyamine Levels |
| Autor(es) |
Herrero, Ana B.
López, M. Carmen
GarcÃa, Susana
Schmidt, Axel
Spaltmann, Frank
Ruiz-Herrera, José
Dominguez, Angel
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96821
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Candida albicans, the most common fungal pathogen, regulates its cellular morphology in response to environmental conditions. The ODC gene, which encodes ornithine decarboxylase, a key enzyme in polyamine biosynthesis, was isolated and disrupted. Homozygous null Candida mutants behaved as polyamine auxotrophs and grew exclusively in the yeast form at low polyamine levels (0.01 mM putrescine) under all conditions tested. An increase in the polyamine concentration (10 mM putrescine) restored the capacity to switch from the yeast to the filamentous form. The strain with a deletion mutation also showed increased sensitivity to salts and calcofluor white. This Candida odc/odc mutant was virulent in a mouse model. The results suggest a model in which polyamine levels exert a pleiotrophic effect on transcriptional activity.
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| Palabras clave |
Fungal and Parasitic Infections
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 1999, American Society for Microbiology |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
08-feb-2008 |
| Contacto |
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