Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance
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Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance
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| Id. |
17654135 |
| Idioma |
inglés
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| Titulo |
Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance |
| Autor(es) |
van Remoortere, Alexandra
van Dam, Govert J.
Hokke, Cornelis H.
van den Eijnden, Dirk H.
van Die, Irma
Deelder, André M.
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98171
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
We report here that sera of children and adults infected with Schistosoma mansoni, S. haematobium, or S. japonicum contain antibodies against GalNAcβ1-4(Fucα1-2Fucα1-3)GlcNAc (LDN-DF) and to a lesser extent to Galβ1-4(Fucα1-3)GlcNAc (Lewisx) and GalNAcβ1-4GlcNAc (LDN). Surface plasmon resonance (SPR) spectroscopy was used to monitor the presence of serum antibodies to neoglycoconjugates containing these carbohydrate epitopes and to define the immunoglobulin M (IgM) and IgG subclass distribution of the antibodies. The serum levels of antibodies to LDN-DF are high related to LDN and Lewisx for all examined groups of Schistosoma-infected individuals. A higher antibody response to the LDN-DF epitope was found in sera of infected children than in sera of infected adults regardless of the schistosome species. With respect to the subclasses, we found surprisingly that individuals infected with S. japonicum have predominantly IgG antibodies, while individuals infected with S. mansoni mainly show an IgM response; high levels of both isotypes were measured in sera of individuals infected with S. haematobium. These data provide new insights in the human humoral immune response to schistosome-derived glycans.
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| Palabras clave |
Fungal and Parasitic Infections
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2001, American Society for Microbiology |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
08-feb-2008 |
| Contacto |
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