Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures
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Detalles del recurso
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Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures
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| Id. |
38184142 |
| Idioma |
inglés
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| Titulo |
Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures |
| Autor(es) |
Tapia Villanueva, Cristián
Corbalán, V.
Costa, E.
Gai, María Nella
Yazdani Pedram, M.
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| Localización |
AMER CHEMICAL SOC
1525-7797
http://hdl.handle.net/2250/5279
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
The aim of this work was to establish the diltiazem hydrochloride release mechanism from the chitosan-alginate matrix tablet (MCB/AS) and chitosan-carrageenan matrix tablet (MCS/CSI). The weight loss for MCS/CSI is mainly due to the weight loss of the matrix while for MCB/AS it is mainly due to the diltiazem hydrochloride released from the tablet. Using the Peppa's model the release order for MCS/CSI was n = 1.07 +/- 0.13 and for MCB/AS was n = 0.76 +/- 0.02. Thus, MCS/CSI has a transport mechanism, and for MCB/AS the drug release mechanism is a combined process of diffusion and relaxation. MCB/AS has an elastic modulus (G' = 10(5) Pa) one order of magnitude higher than MCS/CSI (G' = 10(4) Pa). MCB/AS is able to uptake solvent without disrupting the microstructure due to its high elastic modulus. Instead MCS/ CSI showed a quick erosion process, which conducted to the tablet disintegration due to a fast solvent uptake process.
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| Palabras clave |
Diltiazemhydrochloride
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| Tipo de recurso |
Article
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
12-ago-2009 |
| Contacto |
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