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Descripción: Future space missions will involve long-term travel beyond the magnetic field of the Earth, where astronauts will be exposed to radiation hazards such as those that arise from galactic cosmic rays. Galactic cosmic rays are composed of protons, alpha particles, and particles of high energy and charge (HZE particles). Research by our group has shown that exposure to HZE particles, primarily 600 MeV/n and 1 GeV/n 56Fe, can produce significant alterations in brain neurochemistry and behavior. However, given that protons can make up a significant portion of the radiation spectrum, it is important to study their effects on neural functioning and on related performance. Therefore, these studies examined the effects of exposure to proton irradiation on neurochemical and behavioral endpoints, including dopaminergic functioning, amphetamine-induced conditioned taste aversion learning, and spatial learning and memory as measured by the Morris water maze. Male Sprague-Dawley rats received a dose of 0, 1.5, 3.0 or 4.0 Gy of 250 MeV protons at Loma Linda University and were tested in the different behavioral tests at various times following exposure. Results showed that there was no effect of proton irradiation at any dose on any of the endpoints measured. Therefore, there is a contrast between the insignificant effects of high dose proton exposure and the dramatic effectiveness of low dose (<0.1 Gy) exposures to 56Fe particles on both neurochemical and behavioral endpoints. Published by Elsevier Ltd on behalf of COSPAR.
Autor(es): Shukitt - Hale, B. - Szprengiel, A. - Pluhar, J. - Rabin, B. M. - Joseph, J. A. -
Id.: 43176300
Versión: 1.0
Estado: Final
Palabras clave: 53 -
Tipo de recurso:
Advances in space research : the official journal of the Committee on Space Research (COSPAR), Volume 33, 1334-9
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Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
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Estructura: Atomic
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Copyright: sí
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Fecha de contribución: 12-may-2009
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