Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems
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Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems
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| Id. |
44856404 |
| Idioma |
inglés
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| Titulo |
Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems |
| Autor(es) |
Tapia, Cristián
Costa, Edda
Yazdani-Pedram, Mehrdad
Ormazabal, Víctor
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| Localización |
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.: 33, issue: 6, p.: 585-593, JUN 2007.
1520-5762 electronic
0363-9045 paper
http://hdl.handle.net/2250/6395
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
The aim of this work was to develop prolonged diltiazem
hydrochloride release matrices based on alginate-gelatin mixtures and establish
the drug release mechanism. The erosion, swelling, and dissolution behavior
of the tablets in different medium were evaluated. The different polyelectrolyte
behavior and gel strength between type A Gelatin and type B Gelatin
would explain the different swelling, erosion and dissolution behavior in the
media with sudden pH change. The similar dissolution behavior in the pH,
which simulates the physiological pH through the gastrointestinal tract,
should be explained because the same main species for gelatin A and Gelatin
B would be present in this media.
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| Palabras clave |
Alginate
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| Tipo de recurso |
Article
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
27-jun-2009 |
| Contacto |
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