Latin American Journal of Pharmacy
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Latin American Journal of Pharmacy
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| Id. |
46766135 |
| Idioma |
Inglés
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| Titulo |
Latin American Journal of Pharmacy |
| Autor(es) |
Oliveira, Bérgson F.
Ferreira, Ana E.R.
Fialho, Sílvia L.
Silva-Cunha, Armando
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| Localización |
http://www.sedici.unlp.edu.ar?id=ARG-FARM-ART-0000001263
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
W/O/W multiple emulsions containing naltrexone (NTX) hydrochloride were prepared by a
two-step emulsification method at 20 ºC. Characterization of the developed system was evaluated and the
release kinetics of the drug was determined. The tissue response to the injection of the multiple emulsion
in mice was observed by histological analysis. The entrapment efficiency of NTX hydrochloride in W/O/W
multiple emulsion was 97.72 ± 0.8 % and the mean diameter of the multiple globules was 18.6 ± 7.7 ?m.
The main in vitro drug release mechanism observed for the developed system is supposed to be a swellingbreakdown
phenomenon after dilution of the emulsions under hypo-osmotic conditions. Biocompatibility
studies showed that the multiple emulsion was well tolerated as no significant toxic reaction was observed.
The W/O/W multiple emulsion containing NTX hydrochloride may represent a potential alternative
dosage form for the treatment of alcohol dependence.
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| Tipo |
text/html
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| Palabras clave |
Alcoholismo
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| Tipo de recurso |
Artículo
Artículo
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Formatos |
text/html
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
07-ago-2009 |
| Contacto |
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