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SciELO Brasil - Scientific Electronic Library Online
Descripción: We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy (P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption
Autor(es): Cendon,S.P. - Battlehner,C. - Lorenzi - Filho,G. - Dohlnikoff,M. - Pereira,P.M. - Conceição,G.M.S. - Beppu,O.S. - Saldiva,P.H.N. -
Id.: 507184
Idioma:
inglés
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Versión: 1.0
Estado: Final
Tipo: text/html -
Palabras clave: passive smoking -
Tipo de recurso:
journal article
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Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
Audiencia:
Estudiante
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Estructura: Atomic
Coste: no
Copyright: sí
Formatos: text/html -
Requerimientos técnicos: Browser: Any -
Fecha de contribución: 22-may-2005
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