Thursday, August 27, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Pulmonary emphysema induced by passive smoking: an experimental study in rats

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: SciELO Brasil - Scientific Electronic Library Online  

Descripción: We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy (P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption

Autor(es): Cendon,S.P. -  Battlehner,C. -  Lorenzi -  Filho,G. -  Dohlnikoff,M. -  Pereira,P.M. -  Conceição,G.M.S. -  Beppu,O.S. -  Saldiva,P.H.N. - 

Id.: 507184

Idioma: English  - 

Versión: 1.0

Estado: Final

Tipo:  text/html - 

Palabras clavepassive smoking - 

Tipo de recurso: journal article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Formatos:  text/html - 

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 22-may-2005

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. PAPER Diagnosis of canine nasal aspergillosis by cytological examination: a comparison of four different collection techniques OBJEC...
  2. REVIEW CHEYNE-STOKES RESPIRATION IN PATIENTS WITH CONGESTIVE HEART FAILURE: CAUSES AND CONSEQUENCES causes and consequences. Clinics. 2005;60(4): 333-44. Cheyne-Stokes respiration is a form of periodi...
  3. CONTENT ALERTS This article cites 35 articles, 12 of which can be accessed free
  4. Characterizing electrostatic turbulence in tokamak plasmas with high MHD activity Abstract. One of the challenges in obtaining long lasting magnetic confinement of fusion plasmas in ...
  5. EX/8-4Ra Turbulent transport and plasma flow in the Reversed Field Pinch Abstract. The results of an extensive investigation of electrostatic and magnetic turbulence in the ...

Otros recursos de la misma colección

  1. Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not be...
  2. A glycoprotein E gene-deleted bovine herpesvirus 1 as a candidate vaccine strain A bovine herpesvirus 1 (BoHV-1) defective in glycoprotein E (gE) was constructed from a Brazilian ge...
  3. Preventive effect of reduced glutathione on contrast-induced nephropathy in elderly patients undergoing coronary angiography or intervention: a randomized, controlled trial Coronary angiography can be a high-risk condition for the incidence of contrast-induced nephropathy ...
  4. Comparison of conventional Papanicolaou cytology samples with liquid-based cervical cytology samples from women in Pernambuco, Brazil In the present study, we compared the performance of a ThinPrep cytological method with the conventi...
  5. Antibacterial and anti-inflammatory activities of an extract, fractions, and compounds isolated from Gochnatia pulchra aerial parts This paper reports on the in vitro antibacterial and in vivo anti-inflammatory properties of a hydro...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso