Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas
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Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas
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| Id. |
629287 |
| Idioma |
inglés
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| Titulo |
Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas |
| Autor(es) |
Veiga,Luciana CS
Bérgamo,Nádia A
Kowalski,Luiz Paulo
Rogatto,Silvia R
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| Localización |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200003
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Head and neck carcinomas represent the sixth most frequent type of cancer in the world, and 90% are derived from squamous cells (HNSCC). In this study of 15 HNSCC cases, extensive aneuploidy was detected by G banding in most tumors. The most frequently observed numerical changes involved gain of a chromosome 22, and loss of chromosomes Y, 10, 17, and 19. The most frequent structural alteration was del(22)(q13.1). As compared to G-banding, fluorescence in situ hybridization (FISH) proved to be an effective technique for detecting aneuploidy. Interphase FISH with a chromosome 17 centromere probe disclosed a high frequency of monosomy for chromosome 17, in contrast with G-banding, by which clonal monosomy 17 was detected in only three of the tumors. Painting probes for chromosomes 5 and 16 were used to evaluate a selected series of HNSCC in which G-banding analysis had shown marker chromosomes. FISH analysis failed to confirm the origin of the marker chromosomes, but four out of five cases showed a significant loss of chromosomes 5. This difference between FISH and G-banding results may reflect the smaller number of metaphase analyzed as well as the criteria adopted for sorting these metaphases. Therefore results obtained solely by G-banding analysis should be considered with caution. Our data confirmed the involvement of chromosome 17 in head and neck squamous cell carcinomas.
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| Tipo |
text/html
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| Palabras clave |
FISH
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| Tipo de recurso |
journal article
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Formatos |
text/html
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
23-may-2005 |
| Contacto |
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