Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts
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Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts
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| Id. |
17584477 |
| Idioma |
inglés
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| Titulo |
Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts |
| Autor(es) |
Kullmann , Frank
Judex , Martin
Ballhorn , Wibke
Jüsten , Hans-Peter
Wessinghage , Dieter
Welsh, John
Yen, Tim J
Lang , Bernhard
Hittle, Jim C
McClelland, Michael
Gay, Steffen
Schölmerich, Jürgen
Müller-Ladner, Ulf
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17776
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Our aim was to identify specifically expressed genes using RNA arbitrarily primed (RAP)-polymerase chain reaction (PCR) for differential display in patients with rheumatoid arthritis (RA). In RA, amplification of a distinct PCR product suitable for sequencing could be observed. Sequence analysis identified the PCR product as highly homologous to a 434 base pair segment of the human centromere kinesin-like protein CENP-E. Differential expression of CENP-E was confirmed by quantitative reverse transcription PCR, immunohistochemistry and in situ hybridization. CENP-E expression was independent from prednisolone and could not be completely inhibited by serum starvation. RAP-PCR is a suitable method to identify differentially expressed genes in rheumatoid synovial fibroblasts. Also, because motifs of CENP-E show homologies to jun and fos oncogene products and are involved in virus assembly, CENP-E may be involved in the pathophysiology of RA.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 1999 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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