Protection against cartilage and bone destruction by systemic
interleukin-4 treatment in established murine type II collagen-induced
arthritis
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Protection against cartilage and bone destruction by systemic
interleukin-4 treatment in established murine type II collagen-induced
arthritis
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| Id. |
17584480 |
| Idioma |
inglés
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| Titulo |
Protection against cartilage and bone destruction by systemic
interleukin-4 treatment in established murine type II collagen-induced
arthritis |
| Autor(es) |
Joosten, Leo AB
Lubberts, Erik
Helsen, Monique MA
Saxne, Tore
Coenen-de Roo, Christina JJ
Heinegård, Dick
van den Berg, Wim B
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17779
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Destruction of cartilage and bone are hallmarks of human rheumatoid
arthritis (RA), and controlling these erosive processes is the most challenging
objective in the treatment of RA. Systemic interleukin-4 treatment of
established murine collagen-induced arthritis suppressed disease activity and
protected against cartilage and bone destruction. Reduced cartilage pathology
was confirmed by both decreased serum cartilage oligomeric matrix protein
(COMP) and histological examination. In addition, radiological analysis
revealed that bone destruction was also partially prevented. Improved
suppression of joint swelling was achieved when interleukin-4 treatment was
combined with low-dose prednisolone treatment. Interestingly, synergistic
reduction of both serum COMP and inflammatory parameters was noted when
low-dose interleukin-4 was combined with prednisolone. Systemic treatment with
interleukin-4 appeared to be a protective therapy for cartilage and bone in
arthritis, and in combination with prednisolone at low dosages may offer an
alternative therapy in RA.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 1999 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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