Clonal expansion is a characteristic feature of the B-cell repertoire
of patients with rheumatoid arthritis
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Clonal expansion is a characteristic feature of the B-cell repertoire
of patients with rheumatoid arthritis
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| Id. |
17584504 |
| Idioma |
inglés
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| Titulo |
Clonal expansion is a characteristic feature of the B-cell repertoire
of patients with rheumatoid arthritis |
| Autor(es) |
Itoh, Kenji
Patki, Varsha
Furie, Richard A
Chartash, Elliot K
Jain, Rita I
Lane, Lewis
Asnis, Stanley E
Chiorazzi, Nicholas
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17803
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
The present study was designed to analyze the level of B-cell clonal
diversity in patients with rheumatoid arthritis by using HCDR3 (third
complementarity determining region of the rearranged heavy chain variable
region gene) length as a marker. A modified immunoglobulin VH gene
fingerprinting method using either genomic DNA or complementary (c)DNA derived
from B cells of the peripheral blood, synovial fluid, and tissues of several
rheumatoid arthritis patients was employed. These assays permitted the
detection and distinction of numerically expanded B-cell clones from activated
but not numerically expanded B-cell clones. The present data suggest that
B-cell clonal expansion is a common and characteristic feature of rheumatoid
arthritis and that it occurs with increasing frequency from the blood to the
synovial compartments, resulting in a narrowing of the clonal repertoire at the
synovial level. These clonal expansions can involve resting, apparently memory
B cells, as well as activated B cells. Furthermore, some of these individual
expansions can persist over extended periods of time. These findings support
the hypothesis that a chronic ongoing (auto)immune reaction is operative in
rheumatoid arthritis and that this reaction, at least at the B-cell level, may
be unique to each individual joint. A determination of the targets of these
autoimmune reactions may provide valuable clues to help understand the
immunopathogenesis of this disease.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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