Acute-phase serum amyloid A production by rheumatoid arthritis
synovial tissue
|
Descargar SCORM
Este recurso ha sido solicitado 1 veces (0 veces en los últimos 31 días).
Para poder solicitar este recurso debe identificarse como usuario de la biblioteca
|
| |
Ver
Detalles del recurso
|
|
|
Acute-phase serum amyloid A production by rheumatoid arthritis
synovial tissue
|
| Id. |
17584508 |
| Idioma |
inglés
|
| Titulo |
Acute-phase serum amyloid A production by rheumatoid arthritis
synovial tissue |
| Autor(es) |
O'Hara, Rosemary
Murphy, Evelyn P
Whitehead, Alexander S
FitzGerald, Oliver
Bresnihan, Barry
|
| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17807
|
| Versión |
1.0 |
| Estado |
Final
|
| Descripción |
Acute-phase serum amyloid A (A-SAA) is a major component of the
acute-phase response. A sustained acute-phase response in rheumatoid arthritis
(RA) is associated with increased joint damage. A-SAA mRNA expression was
confirmed in all samples obtained from patients with RA, but not in normal
synovium. A-SAA mRNA expression was also demonstrated in cultured RA
synoviocytes. A-SAA protein was identified in the supernatants of primary
synoviocyte cultures, and its expression colocalized with sites of macrophage
accumulation and with some vascular endothelial cells. It is concluded that
A-SAA is produced by inflamed RA synovial tissue. The known
association between the acute-phase response and progressive joint damage may
be the direct result of synovial A-SAA-induced effects on cartilage
degradation.
|
| Palabras clave |
Primary Research
|
| Tipo de recurso |
Text
|
| Tipo de Interactividad |
Expositivo
|
| Nivel de Interactividad |
muy bajo
|
| Audiencia |
Estudiante
Profesor
Autor
|
| Estructura |
Atomic |
| Coste |
no
|
| Copyright |
sí
|
|
Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
|
| Fecha de contribución |
05-feb-2008 |
| Contacto |
|
|
|
|
|
Valoración de los usuarios
No hay ninguna valoración para este recurso. Sea el primero en
valorar este recurso.
|
|
|
|
