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Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

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Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis
Id.	17584509
Idioma	inglés
Titulo	Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis
Autor(es)	Goldbach-Mansky, Raphaela Lee, Jennifer M Hoxworth, Joseph M Smith II, David Duray, Paul Schumacher, Ralph H Yarboro, Cheryl H Klippel, John Kleiner, David El-Gabalawy, Hani S
Localización	http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17808
Versión	1.0
Estado	Final
Descripción	Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.
Palabras clave	Primary Research
Tipo de recurso	Text
Tipo de Interactividad	Expositivo
Nivel de Interactividad	muy bajo
Audiencia	Estudiante Profesor Autor
Estructura	Atomic
Coste	no
Copyright	sí
Requerimientos técnicos	Browser: Any
Fecha de contribución	05-feb-2008
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