Specificity of T cells in synovial fluid: high frequencies of
CD8+ T cells that are specific for certain viral epitopes
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Specificity of T cells in synovial fluid: high frequencies of
CD8+ T cells that are specific for certain viral epitopes
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| Id. |
17584510 |
| Idioma |
inglés
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| Titulo |
Specificity of T cells in synovial fluid: high frequencies of
CD8+ T cells that are specific for certain viral epitopes |
| Autor(es) |
Tan, Linda C
Mowat, Alastair G
Fazou , Chrysoula
Rostron , Tim
Roskell, Helen
Dunbar , P Rod
Tournay, Claire
Romagné, François
Peyrat, Marie-Alix
Houssaint, Elisabeth
Bonneville, Marc
Rickinson, Alan B
McMichael , Andrew J
Callan, Margaret FC
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17809
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
CD8+ T cells dominate the lymphocyte population in
synovial fluid in chronic inflammatory arthritis. It is known that these
CD8+ T cells are often clonally or oligoclonally expanded, but their
specificity and their relevance to the pathogenesis of joint disease has
remained unclear. We found that as many as 15.5% of synovial CD8+ T
cells may be specific for a single epitope from an Epstein-Barr virus lytic
cycle protein. The virus-specific T cells within the joint showed increased
expression of markers of activation and differentiation compared with those in
the periphery, and retained their functional capacity to secrete
proinflammatory cytokines on stimulation. These activated, virus-specific
CD8+ T cells could therefore interact with synoviocytes, either by
cell-cell contact or by a cytokine network, and play a 'bystander'
role in the maintenance of inflammation in patients with arthritis.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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