Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
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Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
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| Id. |
17584512 |
| Idioma |
inglés
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| Titulo |
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset |
| Autor(es) |
Goldbach-Mansky, Raphaela
Lee, Jennifer
McCoy, Angela
Hoxworth, Joseph
Yarboro, Cheryl
Smolen, Josef S
Steiner, Günter
Rosen, Antony
Zhang, Cindy
Ménard, Henri A
Zhou, Zhi Jie
Palosuo, Timo
Van Venrooij, Walther J
Wilder, Ronald L
Klippel, John H
Schumacher, H Ralph
EI-Gabalawy, Hani S
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17811
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a number of rheumatoid arthritis (RA) associated autoantibodies. Serum samples collected at the time of the initial evaluation were tested for rheumatoid factor (RF) and antibodies to Sa (anti-Sa), RA-33, (pro)filaggrin [antifilaggrin antibody (AFA)], cyclic citrullinated peptide (anti-CCP), calpastatin, and keratin [antikeratin antibody (AKA)]. RF had a sensitivity of 66% and a specificity of 87% for RA. Anti-Sa, AFA, and anti-CCP all had a specificity of more than 90%, but a sensitivity of less than 50% for this diagnosis. Overall, there was a high degree of correlation between AFA, AKA, anti-Sa or anti-CCP, this being highest between anti-Sa and anti-CCP (odds ratio, 13.3; P < 0.001). Of the 101 patients who were positive for at least one of these four autoantibodies, 57% were positive for only one. Finally, anti-SA identified a subset of predominantly male RA patients with severe, erosive disease. Anti-SA, AFA and anti-CCP are all specific for early RA but, overall, have little additional diagnostic value over RF alone. Although these antibodies may preferentially recognize citrullinated antigens, the modest degree of concordance between them in individual patient sera suggests that it is unlikely a single antigen is involved in generating these responses.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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