Gene therapy for established murine collagen-induced arthritis by
local and systemic adenovirus-mediated delivery of interleukin-4
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Gene therapy for established murine collagen-induced arthritis by
local and systemic adenovirus-mediated delivery of interleukin-4
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| Id. |
17584553 |
| Idioma |
inglés
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| Titulo |
Gene therapy for established murine collagen-induced arthritis by
local and systemic adenovirus-mediated delivery of interleukin-4 |
| Autor(es) |
Kim, Seon Hee
Evans, Christopher H
Kim, Sunyoung
Oligino, Thomas
Ghivizzani, Steven C
Robbins, Paul D
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17812
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
To determine whether IL-4 is therapeutic in treating established
experimental arthritis, a recombinant adenovirus carrying the gene that encodes
murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle
joints into mice with established collagen-induced arthritis (CIA).
Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of
arthritis and joint swelling compared with saline- and adenoviral control
groups. Local expression of IL-4 also reduced macroscopic signs of joint
inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind
ankle joints resulted in a decrease in disease severity in the untreated front
paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4
resulted in a significant reduction in the severity of early-stage
arthritis.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
| Contacto |
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