IgVH genes from different anatomical regions, with different
histopathological patterns, of a rheumatoid arthritis patient suggest cyclic
re-entry of mature synovial B-cells in the hypermutation process
|
Descargar SCORM
Este recurso ha sido solicitado 1 veces (0 veces en los últimos 31 días).
Para poder solicitar este recurso debe identificarse como usuario de la biblioteca
|
| |
Ver
Detalles del recurso
|
|
|
IgVH genes from different anatomical regions, with different
histopathological patterns, of a rheumatoid arthritis patient suggest cyclic
re-entry of mature synovial B-cells in the hypermutation process
|
| Id. |
17584554 |
| Idioma |
inglés
|
| Titulo |
IgVH genes from different anatomical regions, with different
histopathological patterns, of a rheumatoid arthritis patient suggest cyclic
re-entry of mature synovial B-cells in the hypermutation process |
| Autor(es) |
Souto-Carneiro, Maria M
Krenn, Veit
Hermann, Ralph
König, Achim
Müller-Hermelink, Hans-Konrad
|
| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17813
|
| Versión |
1.0 |
| Estado |
Final
|
| Descripción |
In the present study 55 IgVH genes amplified from three different
anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding
further information on synovial B-cell maturation and recirculation in RA. This
analysis demonstrated somatically mutated IgVh genes in all regions studied,
with amino acid deletions and mixed IgVh molecules, suggesting the existence of
a novel pathway to generate (auto) antibody specificities. Comparison of amino
acid sequences of amplified genes that belong to the VH1 family (with
predominantly the same germline counterpart) exhibited strong homology,
indicating an apparently conserved mutational pattern. This suggests that the
number of antigens that activate B cells in different locations is restricted.
The most striking result was the finding of clonally related sequences in
different anatomical regions, indicating a recirculation of activated B cells
between the different affected joints.
|
| Palabras clave |
Primary Research
|
| Tipo de recurso |
Text
|
| Tipo de Interactividad |
Expositivo
|
| Nivel de Interactividad |
muy bajo
|
| Audiencia |
Estudiante
Profesor
Autor
|
| Estructura |
Atomic |
| Coste |
no
|
| Copyright |
sí
|
|
Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
|
| Fecha de contribución |
05-feb-2008 |
| Contacto |
|
|
|
|
|
Valoración de los usuarios
No hay ninguna valoración para este recurso. Sea el primero en
valorar este recurso.
|
|
|
|
