T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
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T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
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| Id. |
17584555 |
| Idioma |
inglés
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| Titulo |
T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis |
| Autor(es) |
Malmström, Vivianne
Bäcklund, Johan
Jansson, Liselotte
Kihlberg, Jan
Holmdahl, Rikard
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17814
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-? secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
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