The role of X-chromosome inactivation in female predisposition to autoimmunity
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The role of X-chromosome inactivation in female predisposition to autoimmunity
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| Id. |
17584557 |
| Idioma |
inglés
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| Titulo |
The role of X-chromosome inactivation in female predisposition to autoimmunity |
| Autor(es) |
Chitnis, Smita
Monteiro, Joanita
Glass, David
Apatoff, Brian
Salmon, Jane
Concannon, Patrick
Gregersen, Peter K
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17816
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to inadequate thymic deletion. Using a DNA methylation assay, we have examined the X-chromosome inactivation patterns in peripheral blood from normal females (n = 30), female patients with a variety of autoimmune diseases (n = 167). No differences between patients and controls were observed. However, locally skewed X-chromsome inactivation may exist in the thymus, and therefore the underlying hypothesis remains to be disproved.
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| Palabras clave |
Primary Research
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2000 Current Science Ltd |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
05-feb-2008 |
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