Increased Virulence and Competitive Advantage of a/? Over a/a or ?/? Offspring Conserves the Mating System of Candida albicans
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Increased Virulence and Competitive Advantage of a/? Over a/a or ?/? Offspring Conserves the Mating System of Candida albicans
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| Id. |
18384805 |
| Idioma |
inglés
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| Titulo |
Increased Virulence and Competitive Advantage of a/? Over a/a or ?/? Offspring Conserves the Mating System of Candida albicans |
| Autor(es) |
Lockhart, Shawn R.
Wu, Wei
Radke, Joshua B.
Zhao, Rui
Soll, David R.
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| Localización |
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1449611
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
The majority of Candida albicans strains in nature are a/? and must undergo homozygosis to a/a or ?/? to mate. Here we have used a mouse model for systemic infection to test the hypothesis that a/? strains predominate in nature because they have a competitive advantage over a/a and ?/? offspring in colonizing hosts. Single-strain injection experiments revealed that a/? strains were far more virulent than either their a/a or ?/? offspring. When equal numbers of parent a/? and offspring a/a or ?/? cells were co-injected, a/? always exhibited a competitive advantage at the time of extreme host morbidity or death. When equal numbers of an engineered a/a/?2 strain and its isogenic a/a parent strain were co-injected, the a/a/?2 strain exhibited a competitive advantage at the time of host morbidity or death, suggesting that the genotype of the mating-type (MTL) locus, not associated genes on chromosome 5, provides a competitive advantage. We therefore propose that heterozygosity at the MTL locus not only represses white-opaque switching and genes involved in the mating process, but also affects virulence, providing a competitive advantage to the a/? genotype that conserves the mating system of C. albicans in nature.
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| Palabras clave |
Investigations
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2005, Genetics Society of America |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
11-mar-2008 |
| Contacto |
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