Folding thermodynamics of peptides
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Folding thermodynamics of peptides
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| Id. |
20880369 |
| Titulo |
Folding thermodynamics of peptides |
| Autor(es) |
Irbäck, Anders
Mohanty, Sandipan
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| Localización |
http://arxiv.org/abs/q-bio/0412007
Biophys. J. 88 (2005) 1560-1569
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
A simplified interaction potential for protein folding studies at the atomic
level is discussed and tested on a set of peptides with about 20 residues each.
The test set contains both alpha-helical (Trp cage, Fs) and beta-sheet (GB1p,
GB1m2, GB1m3, Betanova, LLM) peptides. The model, which is entirely
sequence-based, is able to fold these different peptides for one and the same
choice of model parameters. Furthermore, the melting behavior of the peptides
is in good quantitative agreement with experimental data. Apparent folded
populations obtained using different observables are compared, and are found to
be very different for some of the peptides (e.g., Betanova). In other cases (in
particular, GB1m2 and GB1m3), the different estimates agree reasonably well,
indicating a more two-state-like melting behavior.
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| Palabras clave |
Quantitative Biology - Biomolecules
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| Tipo de recurso |
Texto Narrativo
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
28-mar-2007 |
| Contacto |
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