Finite size effects on calorimetric cooperativity of two-state proteins
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Finite size effects on calorimetric cooperativity of two-state proteins
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| Id. |
20880370 |
| Titulo |
Finite size effects on calorimetric cooperativity of two-state proteins |
| Autor(es) |
Li, Mai Suan
Klimov, D. K.
Thirumalai, D.
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| Localización |
http://arxiv.org/abs/q-bio/0412008
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Finite size effects on the calorimetric cooperatity of the folding-unfolding
transition in two-state proteins are considered using the Go lattice models
with and without side chains. We show that for models without side chains a
dimensionless measure of calorimetric cooperativity kappa2 defined as the ratio
of the van't Hoff to calorimetric enthalpy does not depend on the number of
amino acids N. The average value of kappa2 is about 3/4 which is lower than the
experimental value kappa2=1. For models with side chains kappa2 approaches
unity as kappa2 \sim N^mu, where exponent mu=0.17. Above the critical chain
length Nc =135 these models can mimic the truly all-or-non folding-unfolding
transition.
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| Palabras clave |
Quantitative Biology - Biomolecules
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| Tipo de recurso |
Texto Narrativo
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
28-mar-2007 |
| Contacto |
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