Clinical information systems are being introduced into nurses’ work at an alarming rate. These systems are implemented with limited input from nurses who provide direct patient care, and without considering human factors in the systems design and implementation process. The need for nurses to be involved at every level of decision-making as it relates to technological innovation into their work is imperative to mitigate system failure and truly support their work. Therefore, the purpose of this paper is two-fold: 1) to discuss evidence that suggests that the nurse is not really viewed as an end user in most clinical information systems implementations and 2) to describe the implications of this misperception to the nurse, organization, and nursing profession.