Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
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Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
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| Id. |
4261456 |
| Idioma |
inglés
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| Titulo |
Antiinflammatory and Immunomodulating Properties of Fungal Metabolites |
| Autor(es) |
Lull, Cristina
Wichers, Harry J.
Savelkoul, Huub F. J.
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| Localización |
http://www.pubmedcentral.gov/articlerender.fcgi?artid=1160565
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
We discuss current information on the ability of extracts and
isolated metabolites from mushrooms to modulate immune responses. This can
result in a more enhanced innate and acquired disease resistance. The major
immunomodulating effects of these active substances derived from mushrooms
include mitogenicity and activation of immune effector cells, such as
lymphocytes, macrophages, and natural killer cells, resulting in the
production of cytokines, including interleukins (ILs), tumor necrosis factor
alpha (TNF)-?, and interferon gamma
(INF)-?. In particular, the ability of selective mushroom
extracts to modulate the differentiation capacity of CD4+ T
cells to mature into TH1 and/or TH2 subsets will
be discussed. As a consequence these extracts
will have profound effects in particular diseases, like chronic
autoimmune TH1-mediated or allergic TH2-mediated
diseases. Immunosuppressive effects by mushroom components have
also been observed. The therapeutic effects of mushrooms, such as
anticancer activity, suppression of autoimmune diseases, and
allergy have been associated with their immunomodulating
effects. However, further studies are needed to determine the
molecular mechanisms of the immunomodulating effects of mushrooms
metabolites both individually and in complex mixtures, for example, extracts.
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| Palabras clave |
Invited Review
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
25-nov-2006 |
| Contacto |
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