HB Vaccination in the Prevention of Viral Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients with Previous HBV Infection
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HB Vaccination in the Prevention of Viral Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients with Previous HBV Infection
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| Id. |
45145530 |
| Idioma |
inglés
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| Titulo |
HB Vaccination in the Prevention of Viral Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients with Previous HBV Infection |
| Autor(es) |
Onozawa, Masahiro
Hashino, Satoshi
Darmanin, Stephanie
Okada, Kohei
Morita, Rena
Takahata, Mutsumi
Shigematsu, Akio
Kahata, Kaoru
Kondo, Takeshi
Tanaka, Junji
Imamura, Masahiro
Asaka, Masahiro
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| Localización |
http://hdl.handle.net/2115/38729
Biology of Blood and Marrow Transplantation. 14(11), 2008, 1226-1230
http://dx.doi.org/10.1016/j.bbmt.2008.08.007
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
HBV-reverse seroconversion (RS) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a frequent late-onset complication in recipients with previous HBV infection. We conducted post-transplant HB vaccine intervention in 38 allo-HSCT recipients with previous HBV infection. Firstly, we followed the recipients without any intervention (historical control) until 2003; hence we commenced HB vaccination. Out of the patients who underwent transplantation after 2003, 13 recipients were immunized by a standard 3-dose regimen after immunosuppressant cessation (vaccine group), while 12 recipients were observed without any intervention (non-vaccine group). Eight of the 13 historical control group recipients and 3 of the 12 non-vaccine group recipients, but none of the 13 vaccine group recipients, suffered HBV-RS. Cumulative risks of HBV-RS at 3 years post-HSCT in the historical control, non-vaccine and vaccine groups were 41%, 39% and 0% respectively (P = 0.022). We therefore conclude that intervention with HB vaccines is significantly effective in preventing post-HSCT HBV-RS.
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| Palabras clave |
hepatitis B virus
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| Tipo de recurso |
article (author version)
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
19-sep-2009 |
| Contacto |
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