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Mammalian motor neurons corelease glutamate and acetylcholine at central synapses
Nishimaru, Hiroshi
Restrepo, Carlos Ernesto
Ryge, Jesper
Yanagawa, Yuchio
Kiehn, Ole
Location: http://www.pubmedcentral.gov/articlerender.fcgi?artid=555035

Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its original discovery >60 years ago, it has been a general notion that acetylcholine is the only transmitter released from MN synapses both peripherally and centrally. Here, we show, using a multidisciplinary approach, that mammalian spinal MNs, in addition to acetylcholine, corelease glutamate to excite Renshaw cells and other MNs but not to excite muscles. Our study demonstrates that glutamate can be released as a functional neurotransmitter from mammalian MNs.

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Mammalian motor neurons corelease glutamate and acetylcholine at central synapses
Id. 5041691
Idioma inglés
Titulo Mammalian motor neurons corelease glutamate and acetylcholine at central synapses
Autor(es) Nishimaru, Hiroshi
Restrepo, Carlos Ernesto
Ryge, Jesper
Yanagawa, Yuchio
Kiehn, Ole
Location http://www.pubmedcentral.gov/articlerender.fcgi?artid=555035
Versión 1.0
Estado Final
Descripción Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its original discovery >60 years ago, it has been a general notion that acetylcholine is the only transmitter released from MN synapses both peripherally and centrally. Here, we show, using a multidisciplinary approach, that mammalian spinal MNs, in addition to acetylcholine, corelease glutamate to excite Renshaw cells and other MNs but not to excite muscles. Our study demonstrates that glutamate can be released as a functional neurotransmitter from mammalian MNs.
Palabras clave Biological Sciences
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Copyright © 2005, The National Academy of Sciences
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Fecha de contribución 24-nov-2006
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