1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

Transmission of prions between mammalian species is thought to be limited by a "species barrier," which depends on differences in the primary structure of prion proteins in the infecting inoculum and the host, Here we demonstrate that a strain of hamster prions thought to be nonpathogenic for conventional mice leads to prion replication to high levels in such mice but without causing clinical disease. Prions pathogenic in both mice and hamsters are produced. These results demonstrate the existence of subclinical forms of prion infection with important public health implications, both with respect to iatrogenic transmission from apparently healthy humans and dietary exposure to cattle and other species exposed to bovine spongiform encephalopathy prions, Current definitions of the species barrier, which have been based on clinical endpoints, need to be fundamentally reassessed.

Pertenece a

UCL University College London Eprints  

Autor(es)

Hill, AF -  Joiner, S -  Linehan, J -  Desbruslais, M -  Lantos, PL -  Collinge, J - 

Id.: 52395313

Versión: 1.0

Estado: Final

Palabras claveTRANSMISSIBLE MINK ENCEPHALOPATHY, CREUTZFELDT -  JAKOB -  DISEASE, FATAL FAMILIAL INSOMNIA, STRAIN VARIATION, TRANSGENIC MICE, SCRAPIE INFECTIVITY, HAMSTER SCRAPIE, VARIANT CJD, BSE AGENT, PROTEIN - 

Tipo de recurso: Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 08-feb-2012

Contacto:

Localización:

Otros recursos de la mismacolección

  1. NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: A report from the AIEOP-AML group.
  2. Early indicators of self-esteem in teenagers: Findings from a nationally representative sample © 2017 Elsevier LtdThis study explored a longitudinal data set of 3096 British sixteen year olds wit...
  3. Students’ preferences for lecturers’ personalities © 2017 UCUThe present study set out to examine students’ preferences for lecturers’ personality as a...
  4. Health Insurance and Children in Low- and Middle-income Countries: A Review © 2017 Economic Society of Australia.We conduct the first systematic review of the impact of health ...
  5. Extra costs of living with a disability: A systematized review and agenda for research. BACKGROUND: There has been a growing interest in disability and poverty on the international researc...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.