Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive ContactsD?V?
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Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive ContactsD?V?
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| Id. |
5313262 |
| Idioma |
inglés
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| Titulo |
Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive ContactsD?V? |
| Autor(es) |
Scott, Jeanie A.
Shewan, Annette M.
den Elzen, Nicole R.
Loureiro, Joseph J.
Gertler, Frank B.
Yap, Alpha S.
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| Localización |
http://www.pubmedcentral.gov/articlerender.fcgi?artid=1382300
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Functional interactions between classical cadherins and the actin cytoskeleton involve diverse actin activities, including filament nucleation, cross-linking, and bundling. In this report, we explored the capacity of Ena/VASP proteins to regulate the actin cytoskeleton at cadherin-adhesive contacts. We extended the observation that Ena/vasodilator-stimulated phosphoprotein (VASP) proteins localize at cellcell contacts to demonstrate that E-cadherin homophilic ligation is sufficient to recruit Mena to adhesion sites. Ena/VASP activity was necessary both for F-actin accumulation and assembly at cellcell contacts. Moreover, we identified two distinct pools of Mena within individual homophilic adhesions that cells made when they adhered to cadherin-coated substrata. These Mena pools localized with Arp2/3-driven cellular protrusions as well as at the tips of cadherin-based actin bundles. Importantly, Ena/VASP activity was necessary for both modes of actin activity to be expressed. Moreover, selective depletion of Ena/VASP proteins from the tips of cadherin-based bundles perturbed the bundles without affecting the protrusive F-actin pool. We propose that Ena/VASP proteins may serve as higher order regulators of the cytoskeleton at cadherin contacts through their ability to modulate distinct modes of actin organization at those contacts.
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| Palabras clave |
Articles
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2006, The American Society for Cell Biology |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
01-dic-2006 |
| Contacto |
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