Role of a Cdc42p Effector Pathway in Recruitment of the Yeast Septins to the Presumptive Bud SiteD?V?
|
Descargar SCORM
Este recurso ha sido solicitado 1 veces (0 veces en los últimos 31 días).
Para poder solicitar este recurso debe identificarse como usuario de la biblioteca
|
| |
Ver
Detalles del recurso
|
|
|
Role of a Cdc42p Effector Pathway in Recruitment of the Yeast Septins to the Presumptive Bud SiteD?V?
|
| Id. |
5313264 |
| Idioma |
inglés
|
| Titulo |
Role of a Cdc42p Effector Pathway in Recruitment of the Yeast Septins to the Presumptive Bud SiteD?V? |
| Autor(es) |
Iwase, Masayuki
Luo, Jianying
Nagaraj, Satish
Longtine, Mark
Kim, Hyong Bai
Haarer, Brian K.
Caruso, Carlo
Tong, Zongtian
Pringle, John R.
Bi, Erfei
|
| Localización |
http://www.pubmedcentral.gov/articlerender.fcgi?artid=1382302
|
| Versión |
1.0 |
| Estado |
Final
|
| Descripción |
The septins are GTP-binding, filament-forming proteins that are involved in cytokinesis and other processes. In the yeast Saccharomyces cerevisiae, the septins are recruited to the presumptive bud site at the cell cortex, where they form a ring through which the bud emerges. We report here that in wild-type cells, the septins typically become detectable in the vicinity of the bud site several minutes before ring formation, but the ring itself is the first distinct structure that forms. Septin recruitment depends on activated Cdc42p but not on the normal pathway for bud-site selection. Recruitment occurs in the absence of F-actin, but ring formation is delayed. Mutant phenotypes and suppression data suggest that the Cdc42p effectors Gic1p and Gic2p, previously implicated in polarization of the actin cytoskeleton, also function in septin recruitment. Two-hybrid, in vitro protein binding, and coimmunoprecipitation data indicate that this role involves a direct interaction of the Gic proteins with the septin Cdc12p.
|
| Palabras clave |
Articles
|
| Tipo de recurso |
Text
|
| Tipo de Interactividad |
Expositivo
|
| Nivel de Interactividad |
muy bajo
|
| Audiencia |
Estudiante
Profesor
Autor
|
| Estructura |
Atomic |
| Coste |
no
|
| Copyright |
sí
|
|
Copyright © 2006, The American Society for Cell Biology |
| Requerimientos técnicos |
Browser: Any
|
| Fecha de contribución |
01-dic-2006 |
| Contacto |
|
|
|
|
|
Valoración de los usuarios
No hay ninguna valoración para este recurso. Sea el primero en
valorar este recurso.
|
|
|
|
