Sphingoid Base Is Required for Translation Initiation during Heat Stress in Saccharomyces cerevisiaeD?
|
Descargar SCORM
Este recurso ha sido solicitado 1 veces (0 veces en los últimos 31 días).
Para poder solicitar este recurso debe identificarse como usuario de la biblioteca
|
| |
Ver
Detalles del recurso
|
|
|
Sphingoid Base Is Required for Translation Initiation during Heat Stress in Saccharomyces cerevisiaeD?
|
| Id. |
5313268 |
| Idioma |
inglés
|
| Titulo |
Sphingoid Base Is Required for Translation Initiation during Heat Stress in Saccharomyces cerevisiaeD? |
| Autor(es) |
Meier, Karsten D.
Deloche, Olivier
Kajiwara, Kentaro
Funato, Kouichi
Riezman, Howard
|
| Localización |
http://www.pubmedcentral.gov/articlerender.fcgi?artid=1382306
|
| Versión |
1.0 |
| Estado |
Final
|
| Descripción |
Sphingolipids are required for many cellular functions including response to heat shock. We analyzed the yeast lcb1-100 mutant, which is conditionally impaired in the first step of sphingolipid biosynthesis and shows a strong decrease in heat shock protein synthesis and viability. Transcription and nuclear export of heat shock protein mRNAs is not affected. However, lcb1-100 cells exhibited a strong decrease in protein synthesis caused by a defect in translation initiation under heat stress conditions. The essential lipid is sphingoid base, not ceramide or sphingoid base phosphates. Deletion of the eIF4E-binding protein Eap1p in lcb-100 cells restored translation of heat shock proteins and increased viability. The translation defect during heat stress in lcb1-100 was due at least partially to a reduced function of the sphingoid base-activated PKH1/2 protein kinases. In addition, depletion of the translation initiation factor eIF4G was observed in lcb1-100 cells and ubiquitin overexpression allowed partial recovery of translation after heat stress. Taken together, we have shown a requirement for sphingoid bases during the recovery from heat shock and suggest that this reflects a direct lipid-dependent signal to the cap-dependent translation initiation apparatus.
|
| Palabras clave |
Articles
|
| Tipo de recurso |
Text
|
| Tipo de Interactividad |
Expositivo
|
| Nivel de Interactividad |
muy bajo
|
| Audiencia |
Estudiante
Profesor
Autor
|
| Estructura |
Atomic |
| Coste |
no
|
| Copyright |
sí
|
|
Copyright © 2006, The American Society for Cell Biology |
| Requerimientos técnicos |
Browser: Any
|
| Fecha de contribución |
01-dic-2006 |
| Contacto |
|
|
|
|
|
Valoración de los usuarios
No hay ninguna valoración para este recurso. Sea el primero en
valorar este recurso.
|
|
|
|
