???????????????????????????????????????????????0.6 mm??????13°???????????????????????????????????????????????????????????????18F????????????????????????????????????????????????????????????????????????????????????????????????? ??????????FWHM?2.4 mm?FWTM?9.5 mm??????6.8 counts sec –1 MBq–1???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? Recently, small object imaging using positron emitters, such as fluorine-18-2-deoxyglucose, has focused on basic nuclear medicine techniques. We have designed and developed ultra-high-energy high-resolution collimators for small object imaging. Firstly, we produced an ultra-high-energy pinhole collimator. The thickness of the lead shielding was 30 mm. The pinhole diameter of knife-edge aperture was 0.6 mm. The acceptance angle was 13°. This cylinder was equipped with a non-collimator gamma camera at a distance of 30.5 cm. The radius of rotation was 6 cm and the magnification was 5.1 times. In simulation calculations, as the pinhole-object distance decreased, geometric sensitivity increased geometrically. However, as the pinhole-object-distance decreased, field-of-view (FOV) decreased linearly. Spatial resolution was measured using a line source of 18F and was 2.4 mm at full-width-at-half-maximum and 9.5 mm at full-width-at-tenth-maximum. The sensitivity of the system was 6.8 counts sec–1 MBq–1 using a point source of 18F. In addition, sensitivity at the rim of FOV was lower than that at the center. Next, we designed an ultra-high-energy converging collimator. It was found that the converging collimator had uniform sensitivity over the FOV. Also, the FOV at smaller collimator-object distances was not as restricted as the ultra-high-energy pinhole collimator. Thus, we demonstrated that high-resolution images for ultra-high-energy imaging could be acquired using the pinhole collimator. Moreover, we believe that the ultra-high-energy converging collimator could be available for a clinical study.