The systemic fungicide application in the aerial part of soybeanplants, to control the final disease cycle and oidium, is a very common practiceused in the last years among the soybean producers in the Rio Grande do Sul.Therefore the main objective of this research was evaluate the effect onsoybeans of different active principles of fungicide available in the market to thesoybean crop. The present research was conducted during the 2003/2004growing season, in the Technological Center of Cotrijui/ Imeab ? Ijui/RS. It wasadministered pure formulations and mixtures, with the following treatments:control (without application of fungicide); total control with two application, beingone with Pyraclostrobin + Epoxiconazole (Opera), and other withTetraconazole, eighteen days after, both in the doses of 0,5 l/ ha; Difeconazole+ azoxystrobin (Score + Priori), 0,15 + 0,2 l/ha; Pyraclostrobin + Epoxiconazole(Opera) 0,5 l/ha; Tetraconazole (Domark) 0,5 l/ha; Carbendazin +Tebuconazole (Bendazol + Orius) 0,25+ 0,25 l/ha; Tiofanato metilico (Cercobin)0,6 l/ha; Cyproconazole + Azoxistrobin (Priori Xtra) 0,3 l/ha; Tebuconazole(Orius) 0,4 l/ha; Flutriafol (Impact) 0,8 l/ha; Propiconazole + Tryfloxistrobin(Stratego) 0,3 l/ha; Difeconazole (Score) 0,2 l/h, and Azoxystrobin (Priori)0,2 l/ha. The systemic fungicide neither hurt the soybean yield nor thephysiological quality of soybean seed.