Toxoplasma gondiiderived heat shock protein 70 stimulates maturation of murine bone marrowderived dendritic cells via Toll-like receptor 4
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Toxoplasma gondiiderived heat shock protein 70 stimulates maturation of murine bone marrowderived dendritic cells via Toll-like receptor 4
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| Id. |
9142055 |
| Idioma |
inglés
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| Titulo |
Toxoplasma gondiiderived heat shock protein 70 stimulates maturation of murine bone marrowderived dendritic cells via Toll-like receptor 4 |
| Autor(es) |
Aosai, Fumie
Rodriguez Pena, Martha S.
Mun, Hye-Seong
Fang, Hao
Mitsunaga, Tetsuya
Norose, Kazumi
Kang, Hyun Kyu
Bae, Yoe-Sik
Yano, Akihiko
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| Localización |
http://www.pubmedcentral.gov/articlerender.fcgi?artid=1400610
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| Versión |
1.0 |
| Estado |
Final
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| Descripción |
Toxoplasma gondii?derived heat shock protein 70 (T.g.HSP70) induced maturation of bone marrowderived dendritic cells (DCs) of wild-type (WT) C57BL/6 mice as evidenced by an increase in surface expression of MHC class I and II molecules and costimulatory molecules such as CD40, CD80, and CD86. Functionally, decreased phagocytic ability and increased alloreactive T cell stimulatory ability were observed in T.g.HSP70-stimulated DCs. These phenotypic and functional changes of T.g.HSP70-stimulated DCs were demonstrated in Toll-like receptor (TLR) 2- and myeloid differentiation factor 88 (MyD88)-deficient but not TLR4-deficient C57BL/6 mice. DCs from WT and TLR2-deficient but not TLR4-deficient mice produced IL-12 after T.g.HSP70 stimulation. T.g.HSP70-stimulated DCs from WT, TLR2-deficient, and MyD88-deficient, but not TLR4-deficient mice expressed IFN-? mRNA. Thus, T.g.HSP70 stimulates murine DC maturation via TLR4 through the MyD88-independent signal transduction cascade.
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| Palabras clave |
Original Articles
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| Tipo de recurso |
Text
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| Tipo de Interactividad |
Expositivo
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| Nivel de Interactividad |
muy bajo
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| Audiencia |
Estudiante
Profesor
Autor
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| Estructura |
Atomic |
| Coste |
no
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| Copyright |
sí
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Copyright © 2006, Cell Stress Society International |
| Requerimientos técnicos |
Browser: Any
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| Fecha de contribución |
02-dic-2006 |
| Contacto |
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