1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Detalles del recurso


Background: The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a major interest in in vivo imaging of this receptor. A PET tracer would allow non-invasive in vivo visualization and quantification of the MCHR1. The aim of the study was the ex vivo evaluation of the MCHR1 ligand [18F]FE@SNAP as a potential PET tracer for the MCHR1. Methods: [18F]FE@SNAP was injected directly into the jugular vein of awake naïve rats for ex vivo brain autoradiography, biodistribution and additional blood metabolite analysis. Blocking experiments were conducted using the unlabeled MCHR1 ligand SNAP-7941. Results: A high uptake of [18F]FE@SNAP was observed in the lateral hypothalamus and the ventricular system. Both regions were significantly blocked by SNAP-7941. Biodistribution evinced the highest uptake in the kidneys, adrenals, lung and duodenum. Specific blocking with SNAP-7941 led to a significant tracer reduction in the heart and adrenals. In plasma samples, 47.73 ± 6.1 % of a hydrophilic radioactive metabolite was found 45 min after tracer injection. Conclusions: Since [18F]FE@SNAP uptake was significantly blocked in the lateral hypothalamus, there is strong evidence that [18F]FE@SNAP is a highly suitable agent for specific MCHR1 imaging in the central nervous system. Additionally, this finding is supported by the specific blocking in the ventricular system, where the MCHR1 is expressed in the ependymal cells. These findings suggest that [18F]FE@SNAP could serve as a useful imaging and therapy monitoring tool for MCHR1-related pathologies.

Pertenece a

University of Vienna Phaidra  


Philippe, Cécile -  Department fur Pharmazeutische Technologie und Biopharmazie, Fakultat fur Lebenswissenschaften, University of Vienna -  Haeusler, Daniela -  Division of Nuclear Medicine, Department of Biomedical Imaging and Image -  guided Therapy, Medical University of Vienna -  Scherer, Thomas -  Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna -  Fürnsinn, Clemens -  Zeilinger, Markus -  Wadsak, Wolfgang -  Shanab, Karem -  Department fur Pharmazeutische Chemie, Fakultat fur Lebenswissenschaften, University of Vienna -  Spreitzer, Helmut -  Hacker, Marcus -  Mitterhauser, Markus - 

Id.: 69790065

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo:  application/pdf -  2028543 bytes - 

Tipo de recurso: article  -  publishedVersion  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: CC BY 4.0 International

Formatos:  application/pdf -  2028543 bytes - 

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] ISSN:2191-219X
[IsBasedOn] EJNMMI Research 6 (2016)

Fecha de contribución: 15-abr-2017


* o:527629
* doi:10.1186/s13550-016-0186-7
* ISSN: 2191-219X
* hdl:11353/10.527629

Otros recursos del mismo autor(es)

  1. Dipyrazolo[1,5-a:4',3'-c]pyridines – a new heterocyclic system accessed via multicomponent reaction The synthesis of dipyrazolo[1,5-a:4',3'-c]pyridines is described. Easily obtainable 5-alkynylpyrazol...
  2. Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles The tetrahedral intermediates generated upon the addition of halolithium carbenoids (LiCH2X and LiCH...
  3. On Detecting Abrupt Changes in Network Entropy Time Series Part 2: Work in Progress
  4. Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides The cytotoxicity of 27 benzanilides and dithiobenzanilides built on a stilbene scaffold and possessi...
  5. Transcriptomic and Proteomic Analysis of Arion vulgaris—Proteins for Probably Successful Survival Strategies? The Spanish slug, Arion vulgaris, is considered one of the hundred most invasive species in Central ...

Otros recursos de la mismacolección

  1. Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides
  2. Nano-coating protects biofunctional materials
  3. Radikal dialogisch. Reflexionen zum Globalen Lernen aus der Perspektive der Pädagogik Paulo Freires Das Bildungskonzept Globales Lernen und Paulo Freires Pädagogik der Unterdrückten weisen eine Reihe ...
  4. Multiwalled Carbon Nanotubes Decorated with Cobalt Oxide Nanoparticles
  5. Stationary Black Holes: Uniqueness and Beyond The spectrum of known black-hole solutions to the stationary Einstein equations has been steadily in...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.