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Descripción

Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we determined that NAT diversification did not occur in the eukaryotes, as all six major human NATs were most likely present in the Last Eukaryotic Common Ancestor (LECA). Furthermore, we also observed that some NATs were actually secondarily lost during evolution of major eukaryotic lineages; therefore, the increased complexity of the higher eukaryotic proteome occurred without a concomitant diversification of NAT complexes.

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Sapientia Repositório Institucional Universidade do Algarve  

Autor(es)

Rathore, Om Singh -  Faustino, Alexandra -  Prudêncio, Pedro -  Van Damme, Petra -  Cox, Cymon J. -  Martinho, Rui Gonçalo - 

Id.: 71518531

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] info:eu-repo/grantAgreement/FCT/3599-PPCDT/125295/PT
[References] info:eu-repo/grantAgreement/FCT/5876/147344/PT
[References] PD/BD/52428/2013
[References] PD/00117/2012
[References] WOS:000369830800001

Fecha de contribución: 20-jul-2018

Contacto:

Localización:
* 2045-2322
* 10.1038/srep21304

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