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Descripción

Metaplastic breast carcinomas (MBCs) are rare malignancies usually with poor prognosis. We report a case of an 18-year-old African female patient who presented with a 34-cm tumor on the right breast. Biopsy showed an extensively necrotic MBC negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (triple negative). A modified right radical mastectomy was performed, followed by adjuvant chemotherapy. Histology confirmed a widely necrotic undifferentiated malignant tumor, with strong and diffuse expression of vimentin and B-cell lymphoma 2, focal high-molecular-weight keratins and focal CD34 expression; Ki67 was >90%. There was no skin, deep margin or lymph node involvement. Six months after surgery, the patient showed a 9 × 7 cm nodule adjacent to the suture and adherent to the anterior chest wall. The tumor was considered unresectable and the patient evolved with rapid systemic deterioration. The patient had a progression-free survival of 6 months and overall survival of 9 months.

Pertenece a

Repositório do Hospital Prof. Doutor Fernando Fonseca  

Autor(es)

Gomes, A -  Santos, V -  Dias, G -  Manso, RT -  Gonçalves, L -  Coiteiro, M -  Gaspar, H -  Nazaré, A - 

Id.: 61327625

Idioma: por  - 

Versión: 1.0

Estado: Final

Palabras claveBreast neoplasms - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294453/pdf/rju141.pdf

Fecha de contribución: 29-ago-2017

Contacto:

Localización:
* J Surg Case Rep. 2015 Jan;1: 1-4
* 10.1093/jscr/rju141.

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