Detalles del recurso

Descripción

Cortisol is released to relay information to cells to regulate metabolism and reaction to stress and inflammation. In particular, cortisol is released in the form of pulsatile signals. This low-energy method of signaling seems to be more efficient than continuous signaling. We hypothesize that there is a controller in the anterior pituitary that leads to pulsatile release of cortisol, and propose a mathematical formulation for such controller, which leads to impulse control as opposed to continuous control. We postulate that this controller is minimizing the number of secretory events that result in cortisol secretion, which is a way of minimizing the energy required for cortisol secretion; this controller maintains the blood cortisol levels within a specific circadian range while complying with the first order dynamics underlying cortisol secretion. We use an ℓ0-norm cost function for this controller, and solve a reweighed ℓ1-norm minimization algorithm for obtaining the solution to this optimization problem. We use four examples to illustrate the performance of this approach: (i) a toy problem that achieves impulse control, (ii) two examples that achieve physiologically plausible pulsatile cortisol release, (iii) an example where the number of pulses is not within the physiologically plausible range for healthy subjects while the cortisol levels are within the desired range. This novel approach results in impulse control where the impulses and the obtained blood cortisol levels have a circadian rhythm and an ultradian rhythm that are in agreement with the known physiology of cortisol secretion. The proposed formulation is a first step in developing intermittent controllers for curing cortisol deficiency. This type of bio-inspired pulse controllers can be employed for designing non-continuous controllers in brain-machine interface design for neuroscience applications.

Pertenece a

DSpace at MIT  

Autor(es)

Faghih, Rose Taj -  Dahleh, Munther A -  Brown, Emery Neal - 

Id.: 70434424

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  http://purl.org/eprint/type/JournalArticle  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Creative Commons Attribution 4.0 International License

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] Frontiers
[References] http://dx.doi.org/10.3389/fnins.2015.00228
[References] Frontiers in Neuroscience

Fecha de contribución: 19-nov-2017

Contacto:

Localización:
* 1662-4548
* 1662-453X
* Faghih, Rose T. et al. "An optimization formulation for characterization of pulsatile cortisol secretion." Frontiers in Neuroscience 9 (August 2015): 228 © 2015 Faghih, Dahleh and Brown
* PUBLISHER_CC

Otros recursos del mismo autor(es)

  1. Brain correlates of autonomic modulation: Combining heart rate variability with fMRI The central autonomic network (CAN) has been described in animal models but has been difficult to el...
  2. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans State-dependent activity of locus ceruleus (LC) neurons has long suggested a role for noradrenergic ...
  3. Multi-neuron intracellular recording in vivo via interacting autopatching robots The activities of groups of neurons in a circuit or brain region are important for neuronal computat...
  4. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness General anesthesia (GA) is a reversible drug-induced state of altered arousal required for more than...
  5. Instantaneous assessment of autonomic cardiovascular control during general anesthesia We present a comprehensive probabilistic point process framework to estimate and monitor the instant...

Otros recursos de la mismacolección

  1. Dynamical zeta functions for Anosov flows via microlocal analysis The purpose of this paper is to give a short microlocal proof of the meromorphic continuation of the...
  2. Measurement of the differential cross section for top quark pair production in pp collisions at $$\sqrt{s} = 8\,\text {TeV} $$ s = 8 TeV © 2015, CERN for the benefit of the CMS collaboration. The normalized differential cross section for...
  3. Information transmission and signal permutation in active flow networks Recent experiments show that both natural and artificial microswimmers in narrow channel-like geomet...
  4. The nature of triad interactions in active turbulence Generalised Navier-Stokes (GNS) equations describing three-dimensional active fluids with flow-depen...
  5. Interferometric inversion: a robust approach to linear inverse problems In this abstract, we present a new approach to linear wavebased inverse problems (e.g. inverse sourc...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.