Friday, April 18, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Anatomic And Genetic Correlates Of The Endocochlear Potential In Recombinant Inbred Mice

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso

Detalles del recurso

Pertenece a: The KnowledgeBank at OSU  

Descripción: Since the endocochlear potential (EP) cannot be measured in humans, mouse models offer a useful way to investigate the pathophysiology of strial presbycusis and to potentially identify responsible genes. Two inbred strains of mice (C57BL/6J and BALB/cJ) have been shown to differ in terms of the EP and strial anatomical correlates. In contrast to C57BL/6J (B6) mice, BALB/cJ (BALB) mice have a lower EP, which coincides with a decreased number of marginal cells and a thinner spiral ligament in BALBs. To further investigate this relationship, and estimate the number of gene(s) responsible for the lower EP in BALBs, 11 recombinant inbred (RI) strains created from crosses between B6 and BALB mice were examined. Cochlear morphometric data gathered for the RI strains suggest that the responsible genes most prominently influence marginal cell density in the stria vascularis. Analysis of EP data using WebQTL online mapping utility revealed a suggestive linkage to a ~7Mb segment of Chromosome 12 (provisionally named Nvep1) and a suggestive linkage to Chromosome 15 (Nvep2). Analysis of marginal cell data using WebQTL revealed a suggestive linkage to the same ~7Mb segment of Chromosome 12 (Nvep1). Since Nvep1 maps to same general location as does marginal cell density, this supports the suggestion that subtle differences in marginal cell density (or a related property) in part determine the EP. Since marginal cell density corresponds to both the 'low normal' EP in young BALBs as well as age-associated EP decline in BALBs, the Nvep1 region may encompass a 'strial presbycusis' predisposing gene.

Autor(es): Kiener, Anna L. - 

Id.: 55239745

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Tipo de recurso: Other  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 05-may-2012

Contacto:

Localización:


Otros recursos que te pueden interesar

  1. FIVE Applications of Wilf-Zeilberger Theory to Enumeration and Probability In the old days, when one had to find some sequence, a(n), there were two extremes. In the lucky cas...
  2. Wavelet transforms associated to group representations and functions invariant under symmetry groups
  3. Prym varieties and their moduli
  4. Polygonal matrix decompositions: Algorithms and . . .
  5. Linearization of . . . interpolating matrix polynomials This paper considers interpolating matrix polynomials P (λ) in Lagrange and Hermite bases. A classic...

Otros recursos de la misma colección

  1. Children with developmental disabilities as candidates for cochlear implantation In recent years, the number of children with multiple disabilities and severe to profound hearing lo...
  2. Protective effect of systemic administration of pravastatin against noise-induced hearing loss in the Fischer 344/NHsd rat substrain The deleterious effects of noise-induced hearing loss (NIHL) on the auditory system have been well d...
  3. A progressive look at increasing follow-up after universal newborn hearing screening referrals Universal Newborn Hearing Screening (UNHS) has continued to grow in the United States to be a very s...
  4. The prevalence of noise induced hearing loss and the need for a health promotion/hearing conservation program for adults With the population of older adults over 65 years of age reaching 40 million individuals in 2010, mu...
  5. Counseling: a vital component to aural rehabilitation across the lifespan for the hearing impaired and their families The purpose of this document was to examine the importance of counseling as part of the aural rehabi...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso