Sunday, September 21, 2014

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


Anatomic And Genetic Correlates Of The Endocochlear Potential In Recombinant Inbred Mice

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso

Detalles del recurso

Pertenece a: The KnowledgeBank at OSU  

Descripción: Since the endocochlear potential (EP) cannot be measured in humans, mouse models offer a useful way to investigate the pathophysiology of strial presbycusis and to potentially identify responsible genes. Two inbred strains of mice (C57BL/6J and BALB/cJ) have been shown to differ in terms of the EP and strial anatomical correlates. In contrast to C57BL/6J (B6) mice, BALB/cJ (BALB) mice have a lower EP, which coincides with a decreased number of marginal cells and a thinner spiral ligament in BALBs. To further investigate this relationship, and estimate the number of gene(s) responsible for the lower EP in BALBs, 11 recombinant inbred (RI) strains created from crosses between B6 and BALB mice were examined. Cochlear morphometric data gathered for the RI strains suggest that the responsible genes most prominently influence marginal cell density in the stria vascularis. Analysis of EP data using WebQTL online mapping utility revealed a suggestive linkage to a ~7Mb segment of Chromosome 12 (provisionally named Nvep1) and a suggestive linkage to Chromosome 15 (Nvep2). Analysis of marginal cell data using WebQTL revealed a suggestive linkage to the same ~7Mb segment of Chromosome 12 (Nvep1). Since Nvep1 maps to same general location as does marginal cell density, this supports the suggestion that subtle differences in marginal cell density (or a related property) in part determine the EP. Since marginal cell density corresponds to both the 'low normal' EP in young BALBs as well as age-associated EP decline in BALBs, the Nvep1 region may encompass a 'strial presbycusis' predisposing gene.

Autor(es): Kiener, Anna L. - 

Id.: 55239745

Idioma: English (United States)  - 

Versión: 1.0

Estado: Final

Tipo de recurso: Other  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] Ohio State University. Department of Speech and Hearing Science. Doctor of Audiology Capstone Projects. 2012

Fecha de contribución: 23-abr-2014

Contacto:

Localización:


Otros recursos que te pueden interesar

  1. Robocasting of biomimetic hydroxyapatite scaffolds using self-setting inks Low temperature self-setting ceramic inks have been scarcely investigated for solid freeform fabrica...
  2. Dewatering of a deep excavation undertaken in a layered soil In order to carry out deep excavations under the water table in urban environments, the safety of th...
  3. Design and facile solid-phase synthesis of peptide-based LPS-inhibitors containing PEG-like functionalities LPS release from Gram-negative bacteria can result in sepsis, a serious systemic inflammatory respon...
  4. Significantly improved dehydrogenation of ball-milled MgH2 doped with CoFe2O4 nanoparticles CoFe2O4 nanoparticles are added to magnesium hydride (MgH2) by high-energy ball milling in order to ...
  5. Stress relaxation analysis of adhesively bonded anchorages for CFRP tendons An adhesively bonded anchor for Carbon Fibre Reinforced Polymer (CFRP) tendons was investigated unde...

Otros recursos de la misma colección

  1. A Comprehensive Review of the Vestibular System The vestibular system is housed within the bony labyrinth of the inner ear and is made up of three s...
  2. The Speech Critical Band (S-CB) in Cochlear Implant Users: Frequency Resolution Employed During the Reception of Everyday Speech It is widely recognized that cochlear implant (CI) users have limited spectral resolution and that t...
  3. The Effect of a Contract on Patient Compliance in an Auditory Training Program The purpose of the present study was to assess the effect of a signed contract on patient compliance...
  4. Parent Experience with a Dual Diagnosis of Autism Spectrum Disorder and Hearing Impairment The aim of the present study was to evaluate the experiences of parents raising children with a dual...
  5. Binaural Auditory Processing Among Middle-­Aged Adults Binaural listening, or listening with both ears, allows a listener to better localize and understand...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso