1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Detalles del recurso

Descripción

It is becoming increasingly clear that plants ranging across the plant kingdom produce anionic host defence peptides (AHDPs) with potent activity against a wide variety of human cancers cells. In general, this activity involves membrane partitioning by AHDPs, which leads to membranolysis and / or internalization to attack intracellular targets such as DNA. Several models have been proposed to describe these events including: the toroidal pore and Shai-Matsuzaki-Huang mechanisms but, in general, the mechanisms underpinning the membrane interactions and anticancer activity of these peptides are poorly understood. Plant AHDPs with anticancer activity can be conveniently discussed with reference to two groups: cyclotides, which possess cyclic molecules stabilized by cysteine knot motifs, and other ADHPs that adopt extended and α-helical conformations. Here, we review research into the anticancer action of these two groups of peptides along with current understanding of the mechanisms underpinning this action.

Pertenece a

Faculty of Technology ePrints Service  

Autor(es)

Harris, Frederick -  Prabhu, Saurabh -  R. Dennison, Sarah -  J. Snape, Timothy -  Lea, Robert -  Mura, Manuela -  A. Phoenix, David - 

Id.: 69957518

Versión: 1.0

Estado: Final

Palabras claveB200 Pharmacology, Toxicology and Pharmacy - 

Tipo de recurso: Article  -  PeerReviewed  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://eprints.lincoln.ac.uk/27986/
[References] 10.2174/0929866523666160511151215

Fecha de contribución: 29-ago-2017

Contacto:

Localización:
* Harris, Frederick and Prabhu, Saurabh and R. Dennison, Sarah and J. Snape, Timothy and Lea, Robert and Mura, Manuela and A. Phoenix, David (2016) Anionic host defence peptides from the plant kingdom: their anticancer activity and mechanisms of action. Protein & Peptide Letters, 23 (8). pp. 676-687. ISSN 0929-8665

Otros recursos del mismo autor(es)

  1. Thymopentin nanoparticles engineered with high loading efficiency, improved pharmacokinetic properties, and enhanced immunostimulating effect using soybean phospholipid and PHBHHx polymer Formulation of protein and peptide drugs with sustained release properties is crucial to enhance the...
  2. Machining medical grade titanium alloys using nonabrasive nanolayered cutting tools The difficulty in machining titanium alloys has led to the development of new cutting tools with tai...
  3. A New and Unusual Pathway for the Reaction of Neocarzinostatin Chromophore with Thiols. Revised Structure of the Protein-Directed Thiol Adduct Neocarzinostatin (holo-NCS) is an antitumor antibiotic comprising a nonprotein chromophore component...
  4. Sloan Digital Sky Survey Imaging of Low Galactic Latitude Fields: Technical Summary and Data Release The Sloan Digital Sky Survey (SDSS) mosaic camera and telescope have obtained five-band optical-wave...
  5. The Second Data Release of the Sloan Digital Sky Survey The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its Second Data Releas...

Otros recursos de la mismacolección

  1. Performance ranking (dis)similarities in commodity markets In this article, we revisit recent evidence indicating that the choice of performance measure appear...
  2. Hypoxia and hypothermia as rival agents of selection driving the evolution of viviparity in lizards Aim: The evolution of key innovations promotes adaptive radiations by opening access to novel ecolog...
  3. Computational microcircuit models of associative memory In healthy and diseased hippocampus .
  4. Simulation as a game design tool In this paper we suggest using gameplay simulations on a logical event level as a design tool alread...
  5. Prometheus induced vorticity in Saturn’s F ring Saturn’s rings are known to show remarkable real time variability in their structure. Many of which ...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.