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The phylum Apicomplexa encompasses numerous important human and animal disease-causing parasites, including the Plasmodium species, and Toxoplasma gondii, causative agents of malaria and toxoplasmosis, respectively. Apicomplexans proliferate by asexual replication and can also undergo sexual recombination. Most life cycle stages of the parasite lack flagella; these structures only appear on male gametes. Although male gametes (microgametes) assemble a typical 9+2 axoneme, the structure of the templating basal body is poorly defined. Moreover, the relationship between asexual stage centrioles and microgamete basal bodies remains unclear. While asexual stages of Plasmodium lack defined centriole structures, the asexual stages of Toxoplasma and closely related coccidian apicomplexans contain centrioles that consist of nine singlet microtubules and a central tubule. There are relatively few ultra-structural images of Toxoplasma microgametes, which only develop in cat intestinal epithelium. Only a subset of these include sections through the basal body: to date, none have unambiguously captured organization of the basal body structure. Moreover, it is unclear whether this basal body is derived from pre-existing asexual stage centrioles or is synthesized de novo. Basal bodies in Plasmodium microgametes are thought to be synthesized de novo, and their assembly remains ill-defined. Apicomplexan genomes harbor genes encoding δ- and ε-tubulin homologs, potentially enabling these parasites to assemble a typical triplet basal body structure. Moreover, the UNIMOD components (SAS6, SAS4/CPAP, and BLD10/CEP135) are conserved in these organisms. However, other widely conserved basal body and flagellar biogenesis elements are missing from apicomplexan genomes. These differences may indicate variations in flagellar biogenesis pathways and in basal body arrangement within the phylum. As apicomplexan basal bodies are distinct from their metazoan counterparts, it may be possible to selectively target parasite structures in order to inhibit microgamete motility which drives generation of genetic diversity in Toxoplasma and transmission for Plasmodium.

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ARCA - Access to Research and Communication Annals - IGC Repository  

Autor(es)

Francia, Maria E. -  Dubremetz, Jean -  Francois -  Morrissette, Naomi S. - 

Id.: 64966876

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveMicrotubule organizing center - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] http://ciliajournal.biomedcentral.com/articles/10.1186/s13630-016-0025-5

Fecha de contribución: 17-feb-2016

Contacto:

Localización:
* 10.1186/s13630-016-0025-5

Otros recursos de la mismacolección

  1. Evolution: Tracing the origins of centrioles, cilia, and flagella This deposit is composed by the main article plus the supplementary materials of the publication.
  2. Centrosomes and cilia in human disease The deposited article is a post-print version (NIH-PA Author Manuscript) and has been submitted to p...
  3. BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair The deposited article is a post-print version and has been submitted to peer review.
  4. A structural road map to unveil basal body composition and assembly The deposited article is a post-print version and has been submitted to peer review.
  5. Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number The deposited article is a post-print version and has been submitted to peer review.

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