Friday, January 30, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía


BMP signaling in the development of the mouse esophagus and forestomach

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia


  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus and forestomach, which are composed of a stratified squamous epithelium. Based on prior work in the skin, we hypothesized that bone morphogenetic protein (BMP) signaling is a central player. To test this hypothesis, we first used a BMP reporter mouse line harboring a BRE-lacZ allele, along with in situ hybridization to localize transcripts for BMP signaling components, including various antagonists. We then exploited a Shh-Cre allele that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function models for the Bmpr1a (Alk3) receptor. In gain-of-function (Shh-Cre;Rosa26CAG-loxpstoploxp-caBmprIa) embryos, high levels of ectopic BMP signaling stall the transition from simple columnar to multilayered undifferentiated epithelium in the esophagus and forestomach. In loss-of-function experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1aflox/flox embryos allows the formation of a multilayered squamous epithelium but this fails to differentiate, as shown by the absence of expression of the suprabasal markers loricrin and involucrin. Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach.

Autor(es): Rodriguez, Pavel -  Da Silva, Susana -  Oxburgh, Leif -  Wang, Fan -  Hogan, Brigid L. M. -  Que, Jianwen - 

Id.: 53939290

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveResearch Report - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 31-jul-2011

Contacto:

Localización:


Otros recursos del mismo autor(es)

  1. Research Article Global Existence and Uniqueness of Strong Solutions for the Magnetohydrodynamic Equations This paper is concerned with an initial boundary value problem in one-dimensional magnetohy-drodynam...
  2. 1 FLUID FIELD ANALYSIS OF HIGH PRESSURE THROTTLE VALVE AND IT’S STRUCTURE IMPROVEMENT* Abstract: The throttle valves used in Tarim Oil Field have many failure problems, such as valve rod...
  3. Genome-wide transcriptomic and phylogenetic analyses reveal distinct aluminum-tolerance mechanisms in the aluminum-accumulating species buckwheat (Fagopyrum tataricum)
  4. and We have benefited from the discussions with Donald Meyer, Catalina Amuedo-Dorantes and from particip...
  5. The Wealth of Nations The greatest improvement in the productive powers of labor, and the greater part of the skill, dexte...

Otros recursos de la misma colección

  1. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development Mesangial cells are specialized pericyte/smooth muscle cells that surround and constrain the vascula...
  2. Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction Effective communication between pre- and postsynaptic compartments is required for proper synapse de...
  3. Translocating myonuclei have distinct leading and lagging edges that require Kinesin and Dynein Nuclei are precisely positioned within all cells, and mispositioned nuclei are a hallmark of many mu...
  4. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development Organ development is a highly regulated process involving the coordinated proliferation and differen...
  5. Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure We demonstrate that ion channels contribute to the regulation of dorsal closure in Drosophila, a mod...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.
 

Busque un recurso