Wednesday, September 17, 2014



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía

BMP signaling in the development of the mouse esophagus and forestomach

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus and forestomach, which are composed of a stratified squamous epithelium. Based on prior work in the skin, we hypothesized that bone morphogenetic protein (BMP) signaling is a central player. To test this hypothesis, we first used a BMP reporter mouse line harboring a BRE-lacZ allele, along with in situ hybridization to localize transcripts for BMP signaling components, including various antagonists. We then exploited a Shh-Cre allele that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function models for the Bmpr1a (Alk3) receptor. In gain-of-function (Shh-Cre;Rosa26CAG-loxpstoploxp-caBmprIa) embryos, high levels of ectopic BMP signaling stall the transition from simple columnar to multilayered undifferentiated epithelium in the esophagus and forestomach. In loss-of-function experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1aflox/flox embryos allows the formation of a multilayered squamous epithelium but this fails to differentiate, as shown by the absence of expression of the suprabasal markers loricrin and involucrin. Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach.

Autor(es): Rodriguez, Pavel -  Da Silva, Susana -  Oxburgh, Leif -  Wang, Fan -  Hogan, Brigid L. M. -  Que, Jianwen - 

Id.: 53939290

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveResearch Report - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 31-jul-2011



Otros recursos del mismo autor(es)

  1. Queries with Arithmetical Constraints In this paper, we study the expressive power and the complexity of first-order logic with arithmetic...
  2. Noname manuscript No. (will be inserted by the editor) Learning Sparse FRAME Models for Natural Image Patterns Abstract It is well known that natural images admit sparse representations by redundant dictionaries...
  3. An efficient and effective nonlinear solver in a parallel software for large scale petroleum reservoir simulation Abstract. We study a parallel Newton-Krylov-Schwarz (NKS) based algorithm for solving large sparse s...
  4. Western Pacific Warm Pool and ENSO Asymmetry in CMIP3 Models Theoretical and empirical studies have suggested that an underestimate of the ENSO asymmetry may be ...
  5. Gpr177 regulates pulmonary vasculature development Establishment of the functional pulmonary vasculature requires intimate interaction between the epit...

Otros recursos de la misma colección

  1. Gpr177 regulates pulmonary vasculature development Establishment of the functional pulmonary vasculature requires intimate interaction between the epit...
  2. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline RNA polymerase II (Pol II) elongation in metazoans is thought to require phosphorylation of serine 2...
  3. Pax7 is regulated by cMyb during early neural crest development through a novel enhancer The neural crest (NC) is a migratory population of cells unique to vertebrates that generates many d...
  4. TEAD4 establishes the energy homeostasis essential for blastocoel formation It has been suggested that during mouse preimplantation development, the zygotically expressed trans...
  5. Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi Striated muscle development requires the coordinated expression of genes involved in sarcomere forma...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.

Busque un recurso