1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus and forestomach, which are composed of a stratified squamous epithelium. Based on prior work in the skin, we hypothesized that bone morphogenetic protein (BMP) signaling is a central player. To test this hypothesis, we first used a BMP reporter mouse line harboring a BRE-lacZ allele, along with in situ hybridization to localize transcripts for BMP signaling components, including various antagonists. We then exploited a Shh-Cre allele that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function models for the Bmpr1a (Alk3) receptor. In gain-of-function (Shh-Cre;Rosa26CAG-loxpstoploxp-caBmprIa) embryos, high levels of ectopic BMP signaling stall the transition from simple columnar to multilayered undifferentiated epithelium in the esophagus and forestomach. In loss-of-function experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1aflox/flox embryos allows the formation of a multilayered squamous epithelium but this fails to differentiate, as shown by the absence of expression of the suprabasal markers loricrin and involucrin. Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach.

Pertenece a

PubMed Central (PMC3 - NLM DTD)  

Autor(es)

Rodriguez, Pavel -  Da Silva, Susana -  Oxburgh, Leif -  Wang, Fan -  Hogan, Brigid L. M. -  Que, Jianwen - 

Id.: 53939290

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras claveResearch Report - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 31-jul-2011

Contacto:

Localización:

Otros recursos del mismo autor(es)

  1. Apoptosis deregulation expression in Philadelphia-negative Myeloproliferative Neoplasms in a Portuguese population Poster presented at the 7th International Conference on Myeloproliferative Neoplasms / European Scho...
  2. DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: the role of base excision repair genes polymorphisms Sob uma licença CC-BY-NC-ND - http://creativecommons.org/licenses/by-nc-nd/4.0/
  3. O ensino do orçamento e as metodologias de ensino Comunicação apresentada em XIII Congresso Internacional de Custos, Porto
  4. Correcting the limited view in optical-resolution photoacoustic microscopy Optical-resolution photoacoustic microscopy (OR-PAM) has proven useful for anatomical and functional...
  5. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations Hypertension is a leading cause of global disease, mortality, and disability. While individuals of A...

Otros recursos de la mismacolección

No existen otros recursos

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.