Saturday, August 1, 2015



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía

BMP signaling in the development of the mouse esophagus and forestomach

1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario
    registrado en Universia

  Descargar recurso

Detalles del recurso

Pertenece a: PubMed Central (PMC3 - NLM DTD)  

Descripción: The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus and forestomach, which are composed of a stratified squamous epithelium. Based on prior work in the skin, we hypothesized that bone morphogenetic protein (BMP) signaling is a central player. To test this hypothesis, we first used a BMP reporter mouse line harboring a BRE-lacZ allele, along with in situ hybridization to localize transcripts for BMP signaling components, including various antagonists. We then exploited a Shh-Cre allele that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function models for the Bmpr1a (Alk3) receptor. In gain-of-function (Shh-Cre;Rosa26CAG-loxpstoploxp-caBmprIa) embryos, high levels of ectopic BMP signaling stall the transition from simple columnar to multilayered undifferentiated epithelium in the esophagus and forestomach. In loss-of-function experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1aflox/flox embryos allows the formation of a multilayered squamous epithelium but this fails to differentiate, as shown by the absence of expression of the suprabasal markers loricrin and involucrin. Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach.

Autor(es): Rodriguez, Pavel -  Da Silva, Susana -  Oxburgh, Leif -  Wang, Fan -  Hogan, Brigid L. M. -  Que, Jianwen - 

Id.: 53939290

Idioma: English  - 

Versión: 1.0

Estado: Final

Palabras claveResearch Report - 

Tipo de recurso: Text  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 31-jul-2011



Otros recursos del mismo autor(es)

  1. Imaging integrin alpha(v)beta(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake Major Projects of Fujian Province Natural Science Foundation [2008-59-11]; National Nature Science F...
  2. A note on the blow-up criterion for the compressible isentropic Navier-Stokes equations with vacuum
  3. Global classical solutions for 3D compressible Navier-Stokes equations with vacuum and a density-dependent viscosity coefficient NNSFC [10801111, 11271306, 10971171]; Fundamental Research Funds for the Central Universities [20101...
  4. GLOBAL CLASSICAL SOLUTIONS TO 3D COMPRESSIBLE MAGNETOHYDRODYNAMIC EQUATIONS WITH LARGE OSCILLATIONS AND VACUUM NNSFC [11171228, 11231006, 11225102, 11271306, 10971171]; Key Project of Beijing Municipal Education...
  5. The zero limits of angular and micro-rotational viscosities for the two-dimensional micropolar fluid equations with boundary effect This paper deals with an initial-boundary value problem to the two-dimensional equations of incompre...

Otros recursos de la misma colección

  1. A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra
  2. Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages
  3. Dose-dependent nuclear β-catenin response segregates endomesoderm along the sea star primary axis In many invertebrates, the nuclearization of β-catenin at one pole of the embryo initiates endomesod...
  4. The cortical hem regulates the size and patterning of neocortex The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (BMP) signaling ...
  5. Harnessing developmental processes for vascular engineering and regeneration The formation of vasculature is essential for tissue maintenance and regeneration. During developmen...

Valoración de los usuarios

No hay ninguna valoración para este recurso.Sea el primero en valorar este recurso.

Busque un recurso