1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

BACKGROUND: B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory) of circulating B cell subsets have not yet been characterized (cell quantification and phenotype identification) in healthy pregnant women. Thus, the objective of our study was to characterize these subsets (as well as regulatory B cells) from late pregnancy to post-partum and to compare them with the circulating B cells of non-pregnant women. METHODS: In all of the enrolled women, flow cytometry was used to characterize the circulating B cell subsets according to the expression of IgD and CD38 (Bm1-Bm5 classification system). Regulatory B cells were characterized based on the expression of surface antigens (CD24, CD27, and CD38) and the production of IL-10 after lipopolysaccharide stimulation. RESULTS: Compared to the absolute counts of B cells in the non-pregnant women (n = 35), those in the pregnant women (n = 43) were significantly lower (p < 0.05) during the 3rd trimester of pregnancy and on delivery day (immediately after delivery). The percentages of these cells on delivery day and at post-partum were significantly lower than those in the non-pregnant women. In general, the absolute counts and percentages of the majority of the B cell subsets were significantly lower in the 3rd trimester of pregnancy and on delivery day than in the non-pregnant women. However, these counts and percentages did not differ significantly between the post-partum and the non-pregnant women. The most notable exceptions to the above were the percentages of naïve B cells (which were significantly higher in the 3rd trimester and on delivery day than in the non-pregnant women) and of CD24(hi)CD38(hi) regulatory B cells (which were significantly higher in the post-partum than in the non-pregnant women). CONCLUSION: According to our study, the peripheral B cell compartment undergoes quantitative changes during normal late pregnancy and post-partum. Such findings may allow us to better understand immunomodulation during human pregnancy and provide evidence that could aid in the development of new strategies to diagnose and treat pregnancy-associated disturbances. Our findings could also be useful for studies of the mechanisms of maternal responses to vaccination and infection.

Pertenece a

Repositório do Hospital Prof. Doutor Fernando Fonseca  

Autor(es)

Lima, J -  Martins, C -  Leandro, MJ -  Nunes, G -  Sousa, MJ -  Branco, J -  Borrego, LM - 

Id.: 69356228

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras clavePregnancy - 

Tipo de recurso: article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: openAccess

Requerimientos técnicos:  Browser: Any - 

Relación: [References] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895979/pdf/12884_2016_Article_927.pdf

Fecha de contribución: 30-nov-2016

Contacto:

Localización:
* BMC Pregnancy Childbirth. 2016 Jun 6;16(1):139
* 1471-2393
* 10.1186/s12884-016-0927-7

Otros recursos del mismo autor(es)

  1. Search for Physics Beyond the Standard Model in Events with High-Momentum Higgs Bosons and Missing Transverse Momentum in Proton-Proton Collisions at 13 TeV A search for physics beyond the standard model in events with one or more high-momentum Higgs bosons...
  2. Search for dark matter in events with energetic, hadronically decaying top quarks and missing transverse momentum at √ s = 13 TeV A search for dark matter is conducted in events with large missing transverse momentum and a hadroni...
  3. Measurement of b hadron lifetimes in pp collisions at $$\sqrt{s} = 8$$s=8 $$\,\text {Te}\text {V}$$TeV Measurements are presented of the lifetimes of the B0, Bs0, Λb0, and Bc+ hadrons using the decay ch...
  4. Search for single production of vector-like quarks decaying to a b quark and a Higgs boson A search is presented for single production of heavy vector-like quarks (B) that decay to a Higgs bo...
  5. Search for lepton flavour violating decays of the Higgs boson to μτ and eτ in proton-proton collisions at √s = 13 TeV A search for lepton flavour violating decays of the Higgs boson in the μτ and eτ decay modes is pres...

Otros recursos de la mismacolección

  1. Tuberculose: a propósito de um caso clínico N/A
  2. Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli. A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-re...
  3. Impact of Labor on Peripheral Blood Maternal T-Cell Subsets and on Regulatory T and B Cells Labor is thought to positively influence immune system development in the offspring, but studies inv...
  4. Mielogramas no HFF: casuística de 2012 a 2016 N/A
  5. Serotype 3 Remains the Leading Cause of Invasive Pneumococcal Disease in Adults in Portugal (2012-2014) Despite Continued Reductions in Other 13-Valent Conjugate Vaccine Serotypes Since 2010 the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent vaccine (PCV7)...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.