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SciELO Brasil - Scientific Electronic Library Online
Descripción: PURPOSE: To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia. MATERIALS AND METHODS: Retrospective study of a group of 143 infertile men with severe oligozoospermia or non-obstructive azoospermia from the Andrology Outpatient Clinic of the Human Reproduction Service at the ABC School of Medicine. Of these patients, 100 had severe oligozoospermia, and 43 non-obstructive azoospermia. All patients underwent a genetic study which included karyotype analysis and Y-microdeletion investigation. RESULTS: Genetic abnormalities were found in 18.8% of the studied patients. Chromosomal abnormalities were found in 6.2% of the patients, being more prevalent in the azoospermia group (11.6%) than in the oligozoospermia group (4%). Chromosomal variants were found in 8.3%, and Y-chromosome microdeletions in 4.2% of patients. CONCLUSION: The high frequency of genetic alterations (18.8%) in our series justified performing a genetic investigation in a population with idiopathic infertility, as results may help determine the prognosis, as well as the choice of an assisted reproduction technique. Moreover, a genetic investigation could minimize the risk of transmitting genetic abnormalities to future generations such as genetic male infertility, mental retardation, genital ambiguity and/or birth defects.
Autor(es): Mafra,Fernanda A. - Christofolini,Denise M. - Bianco,Bianca - Gava,Marcello M. - Glina,Sidney - Belangero,Sintia I. N. - Barbosa,Caio P. -
Id.: 53328003
Idioma:
inglés
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Versión: 1.0
Estado: Final
Tipo: text/html -
Palabras clave: male infertility -
Tipo de recurso:
journal article
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Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
Audiencia:
Estudiante
- Profesor
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Estructura: Atomic
Coste: no
Copyright: sí
Formatos: text/html -
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Fecha de contribución: 27-jul-2011
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