1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso


The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young's modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, P<0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen-water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible.

Pertenece a

UCL University College London Eprints  


Ahmed, T -  Nash, A -  Clark, KE -  Ghibaudo, M -  de Leeuw, NH -  Potter, A -  Stratton, R -  Birch, HL -  Enea Casse, R -  Bozec, L - 

Id.: 69836812

Idioma: eng  - 

Versión: 1.0

Estado: Final

Tipo:  text - 

Palabras claveadvanced glycation end products, aging, atomic force microscopy, collagen, nanomechanics, nanotechnology - 

Tipo de recurso: Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: open

Formatos:  text - 

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] International Journal of Nanomedicine , 12 pp. 3303-3314. (2017)

Fecha de contribución: 20-may-2017



Otros recursos del mismo autor(es)

  1. Measurement of differential cross sections for the production of top quark pairs and of additional jets in √s = 13 TeV Differential and double-differential cross sections for the production of top quark pairs in proton-...
  2. Continental-scale temperature variability during the past two millennia International audience
  3. Temperature variability over Africa during the last 2000 years International audience
  4. A global multiproxy database for temperature reconstructions of the Common Era International audience
  5. Search for Higgs boson pair production in the $\gamma\gamma\mathrm{b\overline{b}}$ final state in pp collisions at $\sqrt{s}=$ 13 TeV A search is presented for the production of a pair of Higgs bosons, where one decays into two photon...

Otros recursos de la mismacolección

  1. NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: A report from the AIEOP-AML group.
  2. Early indicators of self-esteem in teenagers: Findings from a nationally representative sample © 2017 Elsevier LtdThis study explored a longitudinal data set of 3096 British sixteen year olds wit...
  3. Students’ preferences for lecturers’ personalities © 2017 UCUThe present study set out to examine students’ preferences for lecturers’ personality as a...
  4. Health Insurance and Children in Low- and Middle-income Countries: A Review © 2017 Economic Society of Australia.We conduct the first systematic review of the impact of health ...
  5. Extra costs of living with a disability: A systematized review and agenda for research. BACKGROUND: There has been a growing interest in disability and poverty on the international researc...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.