1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia


Opción 1: Descargar recurso

Detalles del recurso

Descripción

Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P < .001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy.

Pertenece a

UCL University College London Eprints  

Autor(es)

Massey, LA -  Micallef, C -  Paviour, DC -  O'Sullivan, SS -  Ling, H -  Williams, DR -  Kallis, C -  Holton, JL -  Revesz, T -  Burn, DJ -  Yousry, T -  Lees, AJ -  Fox, NC -  Jäger, HR - 

Id.: 55229922

Idioma: eng  - 

Versión: 1.0

Estado: Final

Palabras claveAged, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy, Retrospective Studies, Sensitivity and Specificity, Supranuclear Palsy, Progressive - 

Tipo de recurso: Article  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: open

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] Movement Disorders , 27 (14) 1754 - 1762. (2012)

Fecha de contribución: 28-jul-2014

Contacto:

Localización:

Otros recursos del mismo autor(es)

  1. First Searches for Optical Counterparts to Gravitational-wave Candidate Events 24 pages
  2. Implementation and testing of the first prompt search for electromagnetic counterparts to gravitational wave transients 15 pages
  3. Meanderings '95 : rivers of Illinois. A collection of writings by high school students whose teachers and school participated in the River...
  4. Meanderings '95 : rivers of the United States. A collection of writings by high school students whose teachers and school participated in the River...
  5. Meanderings '95 : Illinois/Mississippi River. Funded by National Science Foundation ; awarded to Southern Illinois University at Edwardsville.

Otros recursos de la misma colección

  1. Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM) We present a high content multiwell plate cell-based assay approach to quantify protein interactions...
  2. Eating disorder behaviours amongst adolescents: investigating classification, persistence and prospective associations with adverse outcomes using latent class models Diagnostic criteria for eating disorders (ED) remain largely based on clinical presentations, but do...
  3. Theranostic Fibers for Simultaneous Imaging and Drug Delivery New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnos...
  4. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be as...
  5. Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated wi...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.