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Descripción

HT-1080 fibrosarcoma cells express at their plasma membrane the elastin-binding protein (EBP). Occupancy of EBP by elastin fragments, tropoelastin or XGVAPG peptides was found to trigger procollagenase-1 (proMMP-1) overproduction by HT-1080 cells at the protein and enzyme levels. RT-PCR analysis indicated that elastin peptides did not modify the MMP-1 mRNA steady state levels, suggesting the involvement of a post-transcriptional mechanism. We previously reported that binding of elastin peptides to EBP induced other matrix metalloproteinases (MMP-2 and MT1-MMP) expression. Since those peptides were here found to also accelerate the secretion of urokinase from HT-1080 cells, culture medium was supplemented with plasminogen together with elastin peptides at aims to induce or potentiate MMPs activation cascades. In such conditions, plasmin activity was generated and exacerbate proMMP-1 and proMMP-2 activation. As a consequence, elastin peptides and plasminogen-treated HT-1080 cells displayed a significant type I collagen matrix invasive capacity.

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Autor(es)

Huet, Eric -  Brassart, Bertrand -  Cauchard, Jean -  Hubert -  Debelle, Laurent -  Birembaut, Philippe, -  Wallach, Jean -  Emonard, Herve -  Polette, Myriam, -  Hornebeck, William - 

Id.: 70812180

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras claveMESH  -  Collagen Type I - 

Tipo de recurso: info:eu-repo/semantics/article  -  Journal articles  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] ISSN: 0262-0898
[IsBasedOn] EISSN: 1573-7276
[IsBasedOn] Clinical and Experimental Metastasis
[IsBasedOn] http://www.hal.inserm.fr/inserm-00150356
[IsBasedOn] Clinical and Experimental Metastasis, Springer Verlag, 2002, 19 (2), pp.107-17
[References] info:eu-repo/semantics/altIdentifier/pmid/11964074

Fecha de contribución: 09-feb-2018

Contacto:

Localización:
* inserm-00150356
* PUBMED : 11964074

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