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In the intestine, the mucosal immune system plays essential roles in maintaining homeostasis between the host and microorganisms, and protecting the host from pathogenic invaders. Epithelial cells produce and release a variety of biomolecules into the mucosa and lumen that contribute to immunity. In this review, we focus on a subset of these remarkable host-defense factors–enteric α-defensins, select lectins, mucins, and secretory immunoglobulin A–that have the capacity to bind microbes and thereby contribute to barrier function in the human gut. We provide an overview of the intestinal epithelium, describe specialized secretory cells named Paneth cells, and summarize our current understanding of the biophysical and functional properties of these select microbe-binding biomolecules. We intend for this compilation to complement prior reviews on intestinal host-defense factors, highlight recent advances in the field, and motivate investigations that further illuminate molecular mechanisms as well as the interplay between these molecules and microbes.

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Autor(es)

Chairatana, Phoom -  Nolan, Elizabeth Marie - 

Id.: 70961773

Versión: 1.0

Estado: Final

Tipo de recurso: Article  -  http://purl.org/eprint/type/JournalArticle  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: Creative Commons Attribution-Noncommercial-Share Alike

Requerimientos técnicos:  Browser: Any - 

Relación: [IsBasedOn] PMC
[References] http://dx.doi.org/10.1080/10409238.2016.1243654
[References] Critical Reviews in Biochemistry and Molecular Biology

Fecha de contribución: 04-feb-2018

Contacto:

Localización:
* 1040-9238
* 1549-7798
* Chairatana, Phoom, and Nolan, Elizabeth M. . “Defensins, Lectins, Mucins, and Secretory Immunoglobulin A: Microbe-Binding Biomolecules That Contribute to Mucosal Immunity in the Human Gut.” Critical Reviews in Biochemistry and Molecular Biology 52, 1 (November 2016): 45–56 © 2016 Informa UK Limited, trading as Taylor & Francis Group. Keywords: Mucosal immunity; Paneth cells; host defense; defensins; lectins; mucins; sIgA
* OPEN_ACCESS_POLICY

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