1) La descarga del recurso depende de la página de origen
2) Para poder descargar el recurso, es necesario ser usuario registrado en Universia

Opción 1: Descargar recurso

Opción 2: Descargar recurso

Detalles del recurso


Skeletal muscle myofibers constantly undergo degeneration and regeneration. Histopathological features of 6 skeletal muscles (cranial tibial [CT], gastrocnemius, quadriceps femoris, triceps brachii [TB], lumbar longissimus muscles, and costal part of the diaphragm [CPD]) were compared using C57BL/10ScSn-Dmd (mdx) (mdx) mice, a model for muscular dystrophy versus control, C57BL/10 mice. Body weight and skeletal muscle mass were lower in mdx mice than the control at 4 weeks of age; these results were similar at 6-30 weeks. Additionally, muscular lesions were observed in all examined skeletal muscles in mdx mice after 4 weeks, but none were noted in the controls. Immunohistochemical staining revealed numerous paired box 7-positive satellite cells surrounding the embryonic myosin heavy chain-positive regenerating myofibers, while the number of the former and staining intensity of the latter decreased as myofiber regeneration progressed. Persistent muscular lesions were observed in skeletal muscles of mdx mice between 4 and 14 weeks of age, and normal myofibers decreased with age. Number of muscular lesions was lowest in CPD at all ages examined, while the ratio of normal myofibers was lowest in TB at 6 weeks. In CT, TB, and CPD, Iba1-positive macrophages, the main inflammatory cells in skeletal muscle lesions, showed a significant positive correlation with the appearance of regenerating myofibers. Additionally, B220-positive B-cells showed positive and negative correlation with regenerating and regenerated myofibers, respectively. Our data suggest that degenerative and regenerative features of myofibers differ among skeletal muscles and that inflammatory cells are strongly associated with regenerative features of myofibers in mdx mice.

Pertenece a

Hokkaido University Collection of Scholarly and Academic Papers  


Ikeda, Teppei -  Ichii, Osamu -  Otsuka -  Kanazawa, Saori -  Nakamura, Teppei -  Elewa, Yaser Hosny Ali -  Kon, Yasuhiro - 

Id.: 70125710

Idioma: inglés  - 

Versión: 1.0

Estado: Final

Palabras claveMuscular dystrophy - 

Tipo de recurso: article (author version)  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

: The final publication is available at link.springer.com

Requerimientos técnicos:  Browser: Any - 

Fecha de contribución: 21-oct-2017


* Journal of Muscle Research and Cell Motility, 37(4-5): 153-164

Otros recursos del mismo autor(es)

  1. Design and Evaluation of Mirror Interface MIOSS to Overlay Remote 3D Spaces International audience
  2. Supersymmetry preserving and breaking degenerate vacua, and radiative moduli stabilization We propose a new type of moduli stabilization scenario where the supersymmetric and supersymmetry-br...
  3. Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta Epithelioid cells in the chicken thoracic aorta are chemoreceptor cells that release 5-HT in respons...
  4. Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts. Mitochondria strongly contribute to the maintenance of cellular integrity through various mechanisms...
  5. Constraints on small-field axion inflation We study general class of small-field axion inflations, which are the mixture of polynomial and sinu...

Otros recursos de la mismacolección

  1. Mycotoxin contamination in foodstuffs and feedshealth concerns in Thailand Many studies on mycotoxins have been carried out in various parts of the world. Thailand is one of m...
  2. Pericardial mesothelioma with severe congestive heart failure in a Holstein cow A 58-month-old Holstein cow showed anorexia, edema of the lower jaw and dewlap, jugular venous engor...
  3. The DNA methylation inhibitor 5-aza-2’-deoxycytidine retards cell growth and alters gene expression in canine mammary gland tumor cells Disruption of gene expression by DNA methylation changes is widely involved in tumorigenesis. Here,t...
  4. Effects of semen preservation procedure in egg yolk-tris based extender on bull spermatozoa characteristics To verify the dynamics of damages to spermatozoa during semen freezing, characteristics of spermatoz...
  5. Genomic DNA sex identification in pet red whiskered bulbul (Pycnonotus jocosus) in Thailand The red whiskered bulbul (Pycnonotus jocosus) is a common pet bird in Thailand. Accurate and sensiti...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.