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Gastrointestinal (GI) disturbances are among the most common health challenges faced by the suckling neonate, and dietary interventions aimed to modulate inflammation and microbial colonization may provide a prophylactic option to enhance GI development. The objective of this experiment was to investigate the effects of supplemental ARA or prebiotics (alone or combined) on intestinal inflammation and the microbiome in an acute dextran sodium sulfate (DSS) colitis model. Day-old pigs were randomized among 4 diets (0.5% arachidonic acid (ARA; control); 4g/L galactooligosaccharide + 4 g/L polydextrose (PRE); 2.5% ARA, and PRE+ARA; n=24/diet, and were fed 3 times per d for 21d. On d17-21 pigs (12 per diet) were treated with 0.625 g DSS/kg BW to induce colitis. Pigs were euthanized on d22 and samples were collected for digesta pH, histology, and systemic cytokines. Supplements did not affect growth. There was a main effect of PRE on decreasing ileal, cecal, proximal and distal colon digesta pH compared with diets lacking PRE (7.4 vs. 7.3 ± 0.03; 6.2 vs 5.8 ±0.06; 6.3 vs 5.7 ± 0.04; 6.4 vs. 6.0 ± 0.04, respectively; P<0.05). PRE and DSS both increased laxation scores with highest diarrhea being found in pigs fed PRE and challenged with DSS (P<0.05). In addition, pathology assessments (means ± SEM) showed main effects of diet and DSS on epithelial damage, lamina propria inflammation, crypt abscess, crypt dropout, and overall colitis score (P < 0.05). In conclusion supplementation of formula with prebiotics significantly modulates laxation, histopathology, and digesta pH.

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Chucta, Emily - 

Id.: 69794977

Idioma: inglés (Estados Unidos)  - 

Versión: 1.0

Estado: Final

Palabras claveprebiotics - 

Tipo de recurso: Thesis  - 

Tipo de Interactividad: Expositivo

Nivel de Interactividad: muy bajo

Audiencia: Estudiante  -  Profesor  -  Autor  - 

Estructura: Atomic

Coste: no

Copyright: sí

Requerimientos técnicos:  Browser: Any - 

Relación: [References] The Ohio State University. Department of Animal Sciences Undergraduate Research Theses; 2017

Fecha de contribución: 22-abr-2017



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